TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
about
VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasisRecent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)Molecular motor proteins and amyotrophic lateral sclerosisTherapeutic and diagnostic challenges for frontotemporal dementiaALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formationInteraction of RNA with a C-terminal fragment of the amyotrophic lateral sclerosis-associated TDP43 reduces cytotoxicityThe crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acidsTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy.Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosisCharacterization of a series of 4-aminoquinolines that stimulate caspase-7 mediated cleavage of TDP-43 and inhibit its function.Truncation of the TAR DNA-binding protein 43 is not a prerequisite for cytoplasmic relocalization, and is suppressed by caspase inhibition and by introduction of the A90V sequence variantExposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure.Structural analysis of disease-related TDP-43 D169G mutation: linking enhanced stability and caspase cleavage efficiency to protein accumulation.Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB.Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains.Similar dose-dependence of motor neuron cell death caused by wild type human TDP-43 and mutants with ALS-associated amino acid substitutions.Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosis.Endoplasmic reticulum stress and the ER mitochondrial calcium cycle in amyotrophic lateral sclerosis.The non-death role of metacaspase proteases.The ER mitochondria calcium cycle and ER stress response as therapeutic targets in amyotrophic lateral sclerosis.MOCA is an integrator of the neuronal death signals that are activated by familial Alzheimer's disease-related mutants of amyloid β precursor protein and presenilins.hnRNPA1 autoregulates its own mRNA expression to remain non-cytotoxic.Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) ProteinopathiesThe cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration.Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis.The JNK/c-Jun signaling axis contributes to the TDP-43-induced cell death.TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression.Amyotrophic lateral sclerosis-linked mutant VAPB enhances TDP-43-induced motor neuronal toxicity.Tunicamycin produces TDP-43 cytoplasmic inclusions in cultured brain organotypic slices.The Lysosomal Trafficking Transmembrane Protein 106B Is Linked to Cell Death.Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis.Cell death proteins: an evolutionary role in cellular adaptation before the advent of apoptosis.GPNMB ameliorates mutant TDP-43-induced motor neuron cell death.Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation.
P2860
Q24298739-175D64AB-3260-4AD7-B1FA-AD01AD0C2CD1Q24613709-1200619E-02AF-4B95-865C-340FB3101948Q26820831-C777832F-8087-4FA4-BB86-906224BD895FQ26998919-5539156D-5A77-4F66-9883-8CBB723EDDBFQ27301374-D337AF60-1598-4728-97C4-42EEE9EAEEF5Q27301865-B7A212DD-A7CF-401E-B490-D670CDB31700Q27681463-3640F5D6-EC3A-48E8-9F50-7BF235FBC0BDQ28080628-2478CF67-8C0A-4B50-AE23-2E8E8160099DQ33621868-00290136-D547-467A-A1EB-41F8E0144969Q33987984-033E8026-F91E-427B-8537-0A7E4F8381B6Q35739624-4668E03A-1903-4853-B90E-AC20BE3674C4Q36072010-BDF03782-EB70-4CA7-9CFA-EF443B6CB7B3Q36110068-36F7DD80-8310-4CFB-950A-30C35684794EQ36373142-E3C6ADEF-72CE-4517-B682-485CDDEEFB2DQ36414413-BB83B222-903A-4FE3-B6E4-96616FF05B60Q36588602-6B9F3826-1B06-4140-BF3E-C0DC32F231EBQ36618898-20DEE755-A2E9-417C-83D3-11DB29C1CDEBQ36690906-45CCA61B-F445-4277-8D55-17A5FB2ACC81Q36934643-F2C94A0B-466D-4112-B7D1-FEA38FBF9C03Q37505760-AC01D433-3D4D-402E-8F58-DF93D6B83EECQ37527207-4B045B19-D4E9-4CDE-841C-77BD289D9300Q37915428-A6897FFB-E762-4C57-B18E-CEC37C3AC2B0Q37980249-5B624AB0-FA55-49FC-BCDB-29A658776864Q38030017-DA031872-BF8E-413E-A155-32EC23491E52Q38218666-D66DDA9A-C70A-4D7C-AF1F-9450F19DBFEEQ38330012-CBA07795-40D4-4E7D-897B-9981CDD5B872Q38725109-18A75CFB-1AD6-4B78-BD7A-18D972ED7C41Q38756528-2D1C7FDD-3E82-4F3B-87FC-4A7D24B5D2E0Q38915658-C4F10148-0FFB-4513-97C9-45BC68D31A2AQ39208066-C34C1DC5-4754-4E59-9D90-30F36DD4396FQ39240882-F043D4BA-BCE4-415C-B8AB-37328B28F93EQ39273268-D03C8C76-9F8E-4A00-8CD6-455D7E257AEDQ39447231-F8620149-776C-4491-9BF0-D313876F999AQ39471013-677D84D4-4024-416C-A9EC-407E0E4C6F77Q41878973-A0B1CFAE-4C0B-4C0B-9515-4CC0121010C8Q42089594-DD76ED2C-BA1C-4F36-BCB2-B7C15FACACAFQ44008456-C4AA59AC-ED6A-4493-9EEE-993BA0D65354Q47729229-24BF6FCC-F6B6-45C0-AB1C-3CB97832A43AQ48400960-970709F2-B721-4BBC-8B00-6EED11906E2EQ50969723-4CD36665-9C85-4D7D-8A97-DA10974BAF8C
P2860
TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
TDP-43-induced death is associ ...... pase-mediated TDP-43 cleavage.
@en
TDP-43-induced death is associ ...... pase-mediated TDP-43 cleavage.
@nl
type
label
TDP-43-induced death is associ ...... pase-mediated TDP-43 cleavage.
@en
TDP-43-induced death is associ ...... pase-mediated TDP-43 cleavage.
@nl
prefLabel
TDP-43-induced death is associ ...... pase-mediated TDP-43 cleavage.
@en
TDP-43-induced death is associ ...... pase-mediated TDP-43 cleavage.
@nl
P2093
P2860
P356
P1476
TDP-43-induced death is associ ...... pase-mediated TDP-43 cleavage.
@en
P2093
Hiroaki Suzuki
Masaaki Matsuoka
P2860
P304
13171-13183
P356
10.1074/JBC.M110.197483
P407
P577
2011-02-21T00:00:00Z