Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1.
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Regulation of localization and activity of the microtubule depolymerase MCAKThe KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegansRestoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cellsAurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis.Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation.Mitosis phase enrichment with identification of mitotic centromere-associated kinesin as a therapeutic target in castration-resistant prostate cancer.Mathematical model with spatially uniform regulation explains long-range bidirectional transport of early endosomes in fungal hyphae.PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activityEssential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720.Function of survivin in trophoblastic cells of the placenta.Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localizationCharacterization of adipose-derived stem cells from subcutaneous and visceral adipose tissues and their function in breast cancer cellsAurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis.GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK.Mitotic p21Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation.Dynamic instability--a common denominator in prokaryotic and eukaryotic DNA segregation and cell division.Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles.Intrinsic Disorder in the Kinesin Superfamily.Molecular insight into the regulation and function of MCAK.Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cellsPolo-like kinase 1 regulates the stability of the mitotic centromere-associated kinesin in mitosis.p21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells.Localized Aurora B activity spatially controls non-kinetochore microtubules during spindle assembly.The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch.The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1Polo-like kinase 1 inhibitors, mitotic stress and the tumor suppressor p53.A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition.Tumor suppressor protein p53-mediated repression of human mitotic centromere-associated kinesin gene expression is exerted via down-regulation of Sp1 level.Three Cdk1 sites in the kinesin-5 Cin8 catalytic domain coordinate motor localization and activity during anaphase.Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics.Microtubules cut loose at the cell cortex.
P2860
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P2860
Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Functional and spatial regulat ...... by cyclin-dependent kinase 1.
@en
Functional and spatial regulat ...... by cyclin-dependent kinase 1.
@nl
type
label
Functional and spatial regulat ...... by cyclin-dependent kinase 1.
@en
Functional and spatial regulat ...... by cyclin-dependent kinase 1.
@nl
prefLabel
Functional and spatial regulat ...... by cyclin-dependent kinase 1.
@en
Functional and spatial regulat ...... by cyclin-dependent kinase 1.
@nl
P2093
P2860
P356
P1476
Functional and spatial regulat ...... by cyclin-dependent kinase 1.
@en
P2093
Andrea Krämer
Claire Therese Friel
Claudia Martin
Juping Yuan
Klaus Strebhardt
Mourad Sanhaji
Nina-Naomi Kreis
P2860
P304
P356
10.1128/MCB.00098-10
P407
P577
2010-04-05T00:00:00Z