Notch1 is an effector of Akt and hypoxia in melanoma development. - Wikidata - awgldk - TriplyDB

Notch1 is an effector of Akt and hypoxia in melanoma development.

Notch1 is an effector of Akt and hypoxia in melanoma development.

http://www.wikidata.org/entity/Q39928689

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Experimental selection of hypoxia-tolerant Drosophila melanogaster Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling.Therapeutic Implications of Targeting AKT Signaling in Melanoma Targeting Notch to overcome radiation resistance From fly wings to targeted cancer therapies: a centennial for notch signaling NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.Notch signalling pathway as an oncogenic factor involved in cancer development Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing's sarcoma cells for apoptosis The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma Constitutively active endothelial Notch4 causes lung arteriovenous shunts in mice.NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways.Notch signalling in ischaemia-induced angiogenesis.Melanoma: a model for testing new agents in combination therapies.Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis Role of notch signaling in the maintenance of human mesenchymal stem cells under hypoxic conditions.Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells.Notch inhibitors for cancer treatment.A Notch1-neuregulin1 autocrine signaling loop contributes to melanoma growth.Akt1 mediates neuronal differentiation in zebrafish via a reciprocal interaction with notch signaling Hypoxia, melanocytes and melanoma - survival and tumor development in the permissive microenvironment of the skin.Role of Notch and its oncogenic signaling crosstalk in breast cancer.MicroRNA in Melanoma.Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933.Akt2 regulates all Akt isoforms and promotes resistance to hypoxia through induction of miR-21 upon oxygen deprivation.Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells.Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor UV-Induced Wnt7a in the Human Skin Microenvironment Specifies the Fate of Neural Crest-Like Cells via Suppression of Notch.HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway Therapeutic implications of targeting the PI3Kinase/AKT/mTOR signaling module in melanoma therapy.Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling.Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase A comprehensive transcriptomic analysis of differentiating embryonic stem cells in response to the overexpression of Mesogenin 1 The Role of Hypoxia and Cancer Stem Cells in Renal Cell Carcinoma Pathogenesis.The early antitumor immune response is necessary for tumor growth: Re-visiting Prehn's hypothesis in the human melanoma system.

P2860

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P2860

Notch1 is an effector of Akt and hypoxia in melanoma development.

http://www.wikidata.org/entity/Q39928689

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Notch1 is an effector of Akt and hypoxia in melanoma development.

@en

Notch1 is an effector of Akt and hypoxia in melanoma development.

@nl

type

label

Notch1 is an effector of Akt and hypoxia in melanoma development.

@en

Notch1 is an effector of Akt and hypoxia in melanoma development.

@nl

prefLabel

Notch1 is an effector of Akt and hypoxia in melanoma development.

@en

Notch1 is an effector of Akt and hypoxia in melanoma development.

@nl

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P1433

Journal of Clinical Investigation

P1476

Notch1 is an effector of Akt and hypoxia in melanoma development.

@en

P2093

Amato J Giaccia

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Barbara Bedogni

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Brian J Nickoloff

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James A Warneke

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Marianne Broome Powell

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P2860

Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Mutations of the BRAF gene in human cancer

Notch signaling: cell fate control and signal integration in development

ONCOMINE: a cancer microarray database and integrated data-mining platform

p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas

Hypoxia in cancer: significance and impact on clinical outcome

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

Hypoxia--a key regulatory factor in tumour growth

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3660-3670

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10.1172/JCI36157

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11

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118

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2008-10-16T00:00:00Z

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18924608

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