Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.
about
The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stressNutlin-3a, an MDM2 antagonist and p53 activator, helps to preserve the replicative potential of cancer cells treated with a genotoxic dose of resveratrolTargeting protein serine/threonine phosphatases for drug developmentA chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.WIP1 phosphatase as pharmacological target in cancer therapy.Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures.Phosphatases in the cellular response to DNA damage.Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damageSqualene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 PhosphatasePPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38.PPM1D regulates p21 expression via dephoshporylation at serine 123Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrumRegulation of the Wip1 phosphatase and its effects on the stress response.Optimization of a cyclic peptide inhibitor of Ser/Thr phosphatase PPM1D (Wip1).The WIP1 oncogene promotes progression and invasion of aggressive medulloblastoma variantsThe type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.Genetic variants and mutations of PPM1D control the response to DNA damage.Serine/threonine phosphatases in the DNA damage response and cancer.Wip1 phosphatase in breast cancer.Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability.Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage.PPM1D430, a novel alternative splicing variant of the human PPM1D, can dephosphorylate p53 and exhibits specific tissue expression.PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin.A small molecular scaffold for selective inhibition of Wip1 phosphatase.Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions.Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase.Smaller protein, larger therapeutic potential: PPM1D as a new therapeutic target in brainstem glioma.
P2860
Q24310746-C37BEB0F-5B9F-45CC-A58C-63BF408675B9Q24595171-04B85659-365C-4662-8BAB-9DD226032518Q24658001-64165651-7AF6-482A-882C-8A287CAA0FA8Q33294239-7447C2F1-9AB7-452C-B895-4D5C286BAF8DQ33720757-62FD3C5F-464C-4297-8935-CF0A93B98D47Q33813999-BC87E945-F579-4ABE-9A7D-297630B70DA2Q33952816-166B5993-FFA6-40F3-A71F-1E25994498A8Q34198570-0A6D2A88-1732-4DCB-A494-206DA398283BQ35842531-B6EA280F-25AB-4907-A762-A92B717296F6Q35908249-E83A9052-46B6-405A-916A-02A6822E7DDFQ36108815-F5947A1B-5F66-4853-B3A4-59C6E62BBFC4Q36181526-C9358109-538B-46C7-903A-F3053F7892CAQ36403630-E9BCA412-A9E0-40C3-A457-E2933B154E5FQ36429982-4D9F89E5-04A8-4E1D-9777-C1B082263F84Q36429985-907D5779-D34B-470C-805B-6EA3E0F98FC2Q36490004-8C8E6690-3E00-40E0-8424-9D7134546D27Q36617172-BC260AA7-9C16-4143-BA35-8C9C9B610942Q37396919-BA5D0FBB-FC3C-4572-B006-121A91B9582AQ37788536-CFC8E5E1-883C-46A2-A806-93E68B7ED9CEQ38266298-24E78024-2E81-4FB2-A1F9-8B332D23B1DCQ38963051-865A8674-65D8-417F-8177-EEB0A1B28D95Q39738661-4AF9E6C9-6DEC-4B04-B2CA-A1A49979953FQ39930727-CBDD061F-16CC-46D3-8CBE-AADC6A49E7B3Q41073169-D899B1AC-1362-41D7-8971-A10B1FEA8E44Q41844898-EB8E6B67-1F7F-459D-B654-AFD3F11C3F99Q46299925-D9424875-D8B6-4CE9-A5F7-7A410174CB6DQ46593571-3C4737E7-56AE-4BFA-8BF4-28AE68BE49AAQ48451908-2C250954-5B48-4BD3-8311-500934CF3E0E
P2860
Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Intrinsic kinase activity and ...... or regulation of Chk2 by Wip1.
@en
type
label
Intrinsic kinase activity and ...... or regulation of Chk2 by Wip1.
@en
prefLabel
Intrinsic kinase activity and ...... or regulation of Chk2 by Wip1.
@en
P2093
P2860
P356
P1476
Intrinsic kinase activity and ...... for regulation of Chk2 by Wip1
@en
P2093
Akinori Yoda
Hiroko Fujimoto
Kyoko Toyoshima
Naoko Kato
Nobuyuki Onishi
Takeshi Kondo
Xiao Zhou Xu
Yasuhiro Minami
P2860
P304
24847-24862
P356
10.1074/JBC.M600403200
P407
P50
P577
2006-06-23T00:00:00Z