Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
about
Toward the structure of presenilin/γ-secretase and presenilin homologsCo-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic MiceIdentification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.Presenilin is the molecular target of acidic γ-secretase modulators in living cells.Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteasesNotch3 and HEY-1 as prognostic biomarkers in pancreatic adenocarcinoma.Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell lineMechanism of intramembrane cleavage of alcadeins by γ-secretase.Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane reSubstrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor proteinPhenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1Notch Transmembrane Domain: Secondary Structure and Topology.Notch: from neural development to neurological disorders.The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.Real-time imaging of notch activation with a luciferase complementation-based reporter.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's DiseaseSecond generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production.Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving ProteasesRegulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk.Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.Gamma-secretase inhibition and modulation for Alzheimer's disease.Intramembrane proteolysisSubstrate-targeting gamma-secretase modulatorsInhibition and modulation of gamma-secretase for Alzheimer's diseasePossible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage.Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species.The structure and function of Alzheimer's gamma secretase enzyme complex.Amyloid-modifying therapies for Alzheimer's disease: therapeutic progress and its implications.Novel γ-secretase modulators: a review of patents from 2008 to 2010.γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein ProductionDevelopment and mechanism of γ-secretase modulators for Alzheimer's disease.Therapeutic modulation of Notch signalling--are we there yet?Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulatorsγ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains.Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2
P2860
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P2860
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
@en
type
label
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
@en
prefLabel
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
@en
P2093
P2860
P356
P1476
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
@en
P2093
Akio Fukumori
Harald Steiner
Jingwei Jiang
Masatoshi Takeda
Naohiro Itoh
Ryo Kimura
Shinji Tagami
P2860
P304
P356
10.1074/JBC.M513250200
P407
P577
2006-01-23T00:00:00Z