RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination.
about
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesHuman activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminationsEukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domainRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationA protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae.A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination.RNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeDeletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsProcessing of double-R-loops in (CAG)·(CTG) and C9orf72 (GGGGCC)·(GGCCCC) repeats causes instability.Noncovalent interaction of G-quadruplex DNA with acridine at low concentration monitored by MALDI-TOF mass spectrometry.Generation and characterization of endonuclease G null mice.AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.Strong transcription blockage mediated by R-loop formation within a G-rich homopurine-homopyrimidine sequence localized in the vicinity of the promoter.Mitotic recombination in yeast: elements controlling its incidence.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Linking class-switch recombination with somatic hypermutation.Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5Processing of switch transcripts is required for targeting of antibody class switch recombination.The connection between transcription and genomic instability.Anchoring nascent RNA to the DNA template could interfere with transcriptionDownstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination.Transcription-dependent R-loop formation at mammalian class switch sequences.Determinants of R-loop formation at convergent bidirectionally transcribed trinucleotide repeatsAID to overcome the limitations of genomic information by introducing somatic DNA alterations.Accessibility control and machinery of immunoglobulin class switch recombination.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Complexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids.Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch regionA persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitroAID to overcome the limitations of genomic information.The repetitive portion of the Xenopus IgH Mu switch region mediates orientation-dependent class switch recombinationRNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.The mu switch region tandem repeats are important, but not required, for antibody class switch recombination.Quantitative regulation of class switch recombination by switch region transcription.Inducible DNA breaks in Ig S regions are dependent on AID and UNGMapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factorRegulation of AID, the B-cell genome mutator.Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks.Triggers of IgE class switching and allergy development.
P2860
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P2860
RNA:DNA complex formation upon transcription of immunoglobulin switch regions: implications for the mechanism and regulation of class switch recombination.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
RNA:DNA complex formation upon ...... of class switch recombination.
@en
type
label
RNA:DNA complex formation upon ...... of class switch recombination.
@en
prefLabel
RNA:DNA complex formation upon ...... of class switch recombination.
@en
P2860
P356
P1476
RNA:DNA complex formation upon ...... of class switch recombination.
@en
P2093
P2860
P304
P356
10.1093/NAR/23.24.5006
P577
1995-12-01T00:00:00Z