Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration.
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The catalytic mechanism of hairpin ribozyme studied by hydrostatic pressure.Crystal structure of a hairpin ribozyme-inhibitor complex with implications for catalysisX-ray crystallographic observation of "in-line" and "adjacent" conformations in a bulged self-cleaving RNA/DNA hybrid.A comparison of vanadate to a 2'-5' linkage at the active site of a small ribozyme suggests a role for water in transition-state stabilizationCapturing the structure of a catalytic RNA intermediate: the hammerhead ribozymeThe global structure of the VS ribozyme.Tertiary contacts distant from the active site prime a ribozyme for catalysis.Recent advances in the elucidation of the mechanisms of action of ribozymesA Two-Metal-Ion-Mediated Conformational Switching Pathway for HDV Ribozyme ActivationA further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme.The wide expansion of hepatitis delta virus-like ribozymes throughout trypanosomatid genomes is linked to the spreading of L1Tc/ingi clade mobile elements.Chemical and enzymatic properties of bridging 5'-S-phosphorothioester linkages in DNA.'In-line attack' conformational effect plays a modest role in an enzyme-catalyzed RNA cleavage: a free energy simulation study.A phosphorothioate at the 3' splice-site inhibits the second splicing step in a group I intron.Coupling of fast and slow modes in the reaction pathway of the minimal hammerhead ribozyme cleavage.Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis.Molecular dynamics study displays near in-line attack conformations in the hammerhead ribozyme self-cleavage reactionHammerhead ribozymes: importance of stem-loop II for activity.Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modificationsTheoretical studies of RNA catalysis: hybrid QM/MM methods and their comparison with MD and QM.Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavageMutagenesis and self-ligation of the self-cleavage domain of the satellite RNA minus strand of tobacco ringspot virus and its binding to polyamines.Ion-induced folding of the hammerhead ribozyme: a fluorescence resonance energy transfer study.QM/MM studies of hairpin ribozyme self-cleavage suggest the feasibility of multiple competing reaction mechanisms.Metal ions play a passive role in the hairpin ribozyme catalysed reactionA comparison of the in vitro activity of DNA-armed and all-RNA hammerhead ribozymes.Cleavage properties of an oligonucleotide containing a bridged internucleotide 5'-phosphorothioate RNA linkageProbing the hammerhead ribozyme structure with ribonucleases.Cross-ligation and exchange reactions catalyzed by hairpin ribozymesThe stereochemical course of the first step of pre-mRNA splicing.Identification of a non-junction phosphodiester that influences an autolytic processing reaction of RNA.Phosphorothioate-containing RNAs show mRNA activity in the prokaryotic translation systems in vitro.Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes.Extensive phosphorothioate substitution yields highly active and nuclease-resistant hairpin ribozymes.Extensive molecular dynamics simulations showing that canonical G8 and protonated A38H+ forms are most consistent with crystal structures of hairpin ribozyme.Long-range tertiary interactions in single hammerhead ribozymes bias motional sampling toward catalytically active conformationsThe folding of the hairpin ribozyme: dependence on the loops and the junctionDirect measurement of the ionization state of an essential guanine in the hairpin ribozyme.Morphing the minimal and full-length hammerhead ribozymes: implications for the cleavage mechanism.
P2860
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P2860
Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Two autolytic processing react ...... th inversion of configuration.
@en
type
label
Two autolytic processing react ...... th inversion of configuration.
@en
prefLabel
Two autolytic processing react ...... th inversion of configuration.
@en
P2093
P2860
P356
P1476
Two autolytic processing react ...... th inversion of configuration.
@en
P2093
F Eckstein
G Bruening
J M Buzayan
P A Feldstein
P2860
P304
P356
10.1093/NAR/18.8.1971
P577
1990-04-01T00:00:00Z