Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.
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Toward the structure of presenilin/γ-secretase and presenilin homologsGxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution.Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.Presenilin/gamma-Secretase and Inflammation.A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activityMutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.Structure, mechanism and inhibition of gamma-secretase and presenilin-like proteasesInhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.Presenilin function and gamma-secretase activity.Amyloid precursor protein and BACE function as oligomers.Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk.Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking.Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease.Intramembrane proteolysisGenetics of Alzheimer's disease: an insight into presenilins and apolipoprotein E instigated neurodegeneration.Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.Review: Axon pathology in age-related neurodegenerative disorders.Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants.Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein.Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.Solution Structure of an Intramembrane Aspartyl Protease via Small Angle Neutron Scattering.
P2860
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P2860
Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Functional implications of the ...... ytically inactive presenilins.
@en
type
label
Functional implications of the ...... ytically inactive presenilins.
@en
prefLabel
Functional implications of the ...... ytically inactive presenilins.
@en
P2093
P2860
P356
P1476
Functional implications of the ...... ytically inactive presenilins.
@en
P2093
Carlos A Saura
Esther Pomares
Gemma Marfany
Roser Gonzàlez-Duarte
Sara Cervantes
P2860
P304
36519-36529
P356
10.1074/JBC.M404832200
P407
P577
2004-06-25T00:00:00Z