Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes. - Wikidata - awgldk - TriplyDB

Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

http://www.wikidata.org/entity/Q40568020

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Mutant p53 proteins bind DNA in a DNA structure-selective mode The rebel angel: mutant p53 as the driving oncogene in breast cancer.More targets, more pathways and more clues for mutant p53.Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype.Expression signatures of TP53 mutations in serous ovarian cancers.Mutant p53 gain-of-function in cancer.Oncomorphic TP53 Mutations in Gynecologic Cancers Lose the Normal Protein:Protein Interactions with the microRNA Microprocessing Complex The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes.Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.TP53 oncomorphic mutations predict resistance to platinum‑ and taxane‑based standard chemotherapy in patients diagnosed with advanced serous ovarian carcinoma.Identification of potential synthetic lethal genes to p53 using a computational biology approach Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice.Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.Mutant p53: one name, many proteins.Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma Integrative molecular profiling reveals asparagine synthetase is a target in castration-resistant prostate cancer.Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl NF-kappa B as a target for cancer therapy.Transcription regulation by mutant p53.Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis.DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling The consequence of oncomorphic TP53 mutations in ovarian cancer.Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase.Transcriptional control of the proliferation cluster by the tumor suppressor p53.Chromosome instability and deregulated proliferation: an unavoidable duo.Role of p53 in Cell Death and Human Cancers.Mutant p53 in cancer: new functions and therapeutic opportunities.Wild-type p53 and p73 negatively regulate expression of proliferation related genes.Preferred binding of gain-of-function mutant p53 to bidirectional promoters with coordinated binding of ETS1 and GABPA to multiple binding sites.Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells.Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines Down-regulation of asparagine synthetase induces cell cycle arrest and inhibits cell proliferation of breast cancer.Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.Mutant p53 is a transcriptional co-factor that binds to G-rich regulatory regions of active genes and generates transcriptional plasticity.Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11.Tumor-derived p53 mutants induce NF-kappaB2 gene expression.The R273H p53 mutation can facilitate the androgen-independent growth of LNCaP by a mechanism that involves H2 relaxin and its cognate receptor LGR7.Oncogenomic Approaches in Exploring Gain of Function of Mutant p53.

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Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

http://www.wikidata.org/entity/Q40568020

description

2004 nî lūn-bûn

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Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

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Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

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Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

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Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes

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Debabrita Deb

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Evie H Carchman

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Katherine E R Stagliano

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Kristopher Valerie

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Mariano J Scian

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Michelle A Ellis

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Sumitra Deb

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Swati Palit Deb

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The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation

A model for p53-induced apoptosis

Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase

p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

Functional interaction between DP-1 and p53

Telomerase and breast cancer

p53, the cellular gatekeeper for growth and division

WAF1, a potential mediator of p53 tumor suppression

Surfing the p53 network

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25

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23

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