Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates.
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Function, regulation and pathological roles of the Gab/DOS docking proteinsThe major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signalingIdentification of substrates of human protein-tyrosine phosphatase PTPN22A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activationCellular biochemistry methods for investigating protein tyrosine phosphatasesMining the function of protein tyrosine phosphatases in health and diseaseStructural and functional characterization of a novel phosphatase from the Arabidopsis thaliana gene locus At1g05000Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signalingMultivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cellsCritical role of Shp2 in tumor growth involving regulation of c-MycActivating mutations in protein tyrosine phosphatase Ptpn11 (Shp2) enhance reactive oxygen species production that contributes to myeloproliferative disorderA low molecular weight protein tyrosine phosphatase from Synechocystis sp. strain PCC 6803: enzymatic characterization and identification of its potential substratesHSP70 binds to SHP2 and has effects on the SHP2-related EGFR/GAB1 signaling pathway.Protein-protein interaction between caveolin-1 and SHP-2 is dependent on the N-SH2 domain of SHP-2.Protein tyrosine phosphatase function: the substrate perspective.The tyrosine phosphatase SHP2 regulates focal adhesion kinase to promote EGF-induced lamellipodia persistence and cell migrationRon tyrosine kinase receptor synergises with EGFR to confer adverse features in head and neck squamous cell carcinoma.Molecular mechanism for SHP2 in promoting HER2-induced signaling and transformation.Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase.Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.The tyrosine phosphatase SHP2 associates with CUB domain-containing protein-1 (CDCP1), regulating its expression at the cell surface in a phosphorylation-dependent mannerIsolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors.Requirement of Tyr-992 and Tyr-1173 in phosphorylation of the epidermal growth factor receptor by ionizing radiation and modulation by SHP2.The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3.Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity.SHP2 tyrosine phosphatase converts parafibromin/Cdc73 from a tumor suppressor to an oncogenic driver.Reactive oxygen species and epidermal growth factor are antagonistic cues controlling SHP-2 dimerization.Analysis of protein tyrosine phosphatases and substrates.Modulation of alpha-catenin Tyr phosphorylation by SHP2 positively effects cell transformation induced by the constitutively active FGFR3.Use of Dominant-Negative/Substrate Trapping PTP Mutations to Search for PTP Interactors/Substrates.
P2860
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P2860
Development of an efficient "substrate-trapping" mutant of Src homology phosphotyrosine phosphatase 2 and identification of the epidermal growth factor receptor, Gab1, and three other proteins as target substrates.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Development of an efficient "s ...... proteins as target substrates.
@en
type
label
Development of an efficient "s ...... proteins as target substrates.
@en
prefLabel
Development of an efficient "s ...... proteins as target substrates.
@en
P2860
P356
P1476
Development of an efficient "s ...... proteins as target substrates.
@en
P2093
Michael J Hayman
Yehenew M Agazie
P2860
P304
13952-13958
P356
10.1074/JBC.M210670200
P407
P577
2003-02-11T00:00:00Z