Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells.
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Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells.FAK and paxillin, two potential targets in pancreatic cancerInhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment.Estrogen stimulation of cell migration involves multiple signaling pathway interactionsSignal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells.FERM domain interaction promotes FAK signaling.N-MYC regulates focal adhesion kinase expression in human neuroblastoma.The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis.Phosphorylation of paxillin LD4 destabilizes helix formation and inhibits binding to focal adhesion kinase.Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell linesFocal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasisInhibition of focal adhesion kinase decreases tumor growth in human neuroblastomaFunctional characterization of breast cancer using pathway profilesFAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cellsThe prognostic significance of focal adhesion kinase expression in stage I non-small-cell lung cancerDisruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.Focal adhesion kinase as a potential target in oncology.Targeted inhibition of FAK, PYK2 and BCL-XL synergistically enhances apoptosis in ovarian clear cell carcinoma cell lines.Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.Identification of FAK substrate peptides via colorimetric screening of a one-bead one-peptide combinatorial library.Targeting focal adhesion kinase in neuroblastoma.The interplay between Src and integrins in normal and tumor biology.Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.A systems biology approach for pathway level analysis.Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide.Specific induction of pp125 focal adhesion kinase in human breast cancer.FAK inhibition decreases cell invasion, migration and metastasis in MYCN amplified neuroblastomaA small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeuticsCell survival signaling in neuroblastoma.Preclinical studies of a Pro-antibody-drug conjugate designed to selectively target EGFR-overexpressing tumors with improved therapeutic efficacy.A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.Focal adhesion kinase versus p53: apoptosis or survival?Inhibition of the focal adhesion kinase and vascular endothelial growth factor receptor-3 interaction leads to decreased survival in human neuroblastoma cell lines.MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells.Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing.Focal adhesion kinase and p53 signal transduction pathways in cancer.Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.Focal adhesion kinase as a cancer therapy target.
P2860
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P2860
Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Dual inhibition of focal adhes ...... in human breast cancer cells.
@en
type
label
Dual inhibition of focal adhes ...... in human breast cancer cells.
@en
prefLabel
Dual inhibition of focal adhes ...... in human breast cancer cells.
@en
P2093
P2860
P356
P1476
Dual inhibition of focal adhes ...... in human breast cancer cells.
@en
P2093
H Shelton Earp
Lucia Beviglia
Rolf Craven
Vita Golubovskaya
William Cance
P2860
P304
38978-38987
P356
10.1074/JBC.M205002200
P407
P577
2002-08-07T00:00:00Z