Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.
about
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinAbeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's diseasePresenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formationNeural stem/progenitor cells in Alzheimer's diseaseGamma-secretase complex assembly within the early secretory pathwayPresenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of NotchDopamine-induced α-synuclein oligomers show self- and cross-propagation properties.Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.Amyloid beta protein (Abeta) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects.Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease.Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast.Abeta42 mutants with different aggregation profiles induce distinct pathologies in DrosophilaAcute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation.Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivoThe amyloid precursor protein of Alzheimer's disease and the Abeta peptide.Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer's diseaseCellular cofactors for amyloid beta-peptide-induced cell stress. Moving from cell culture to in vivo.Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 productionInteraction of intracellular beta amyloid peptide with chaperone proteins.The Role of presenilins in gamma-secretase activity.Secretases as therapeutic targets for the treatment of Alzheimer's disease.Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease miceEndoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides.Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro.The amyloid beta ion channel hypothesis of Alzheimer's disease.Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein.A dynamic relationship between intracellular and extracellular pools of Abeta.Evidence for a physical interaction between presenilin and NotchPresenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degenerationIntraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch.Intraneuronal Abeta42 accumulation in human brain.A notable cleavage: winding up with beta-amyloidIncreased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse modelBehavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease.
P2860
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P2860
Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Intracellular generation and a ...... terminating at amino acid 42.
@en
type
label
Intracellular generation and a ...... terminating at amino acid 42.
@en
prefLabel
Intracellular generation and a ...... terminating at amino acid 42.
@en
P2093
P2860
P356
P1476
Intracellular generation and a ...... terminating at amino acid 42.
@en
P2093
P2860
P304
16085-16088
P356
10.1074/JBC.272.26.16085
P407
P577
1997-06-01T00:00:00Z