Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling.
about
cbl-3: a new mammalian cbl family proteinThe Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquiticbl-b inhibits epidermal growth factor receptor signalingLigand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cellsCoordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinasesCbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient miceThe oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.Cbl: many adaptations to regulate protein tyrosine kinases.Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversionThe tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha.A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.Repression of c-Cbl leads to enhanced G-CSF Jak-STAT signaling without increased cell proliferation.The proto-oncogene c-Cbl is a negative regulator of DNA synthesis initiated by both receptor and cytoplasmic tyrosine kinases.Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway.The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: a role for the adaptor protein Crk.Differential effects of Cbl and 70Z/3 Cbl on T cell receptor-induced phospholipase Cgamma-1 activity.Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain.Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins.Regulation of STAT protein synthesis by c-Cbl.
P2860
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P2860
Antisense repression of proto-oncogene c-Cbl enhances activation of the JAK-STAT pathway but not the ras pathway in epidermal growth factor receptor signaling.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Antisense repression of proto- ...... wth factor receptor signaling.
@en
Antisense repression of proto- ...... wth factor receptor signaling.
@nl
type
label
Antisense repression of proto- ...... wth factor receptor signaling.
@en
Antisense repression of proto- ...... wth factor receptor signaling.
@nl
prefLabel
Antisense repression of proto- ...... wth factor receptor signaling.
@en
Antisense repression of proto- ...... wth factor receptor signaling.
@nl
P2093
P2860
P356
P1476
Antisense repression of proto- ...... wth factor receptor signaling.
@en
P2093
K Miyagawa
P2860
P304
P356
10.1074/JBC.272.13.8739
P407
P577
1997-03-01T00:00:00Z