Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.
about
Cathepsin H is an additional convertase of pro-granzyme BGranzymes: a family of lymphocyte granule serine proteasesBehavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T LymphocytesThe 1.8 A crystal structure of human cathepsin G in complex with Suc-Val-Pro-PheP-(OPh)2: a Janus-faced proteinase with two opposite specificitiesSNAREs in the maturation and function of LROsRegulation of CD18 expression on neutrophils in response to fluid shear stressSorting soluble tumor necrosis factor (TNF) receptor for storage and regulated secretion in hematopoietic cells.Identification of a low affinity mannose 6-phosphate-binding site in domain 5 of the cation-independent mannose 6-phosphate receptor.Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Trichosanthin increases Granzyme B penetration into tumor cells by upregulation of CI-MPR on the cell surfaceRegulated secretion from hemopoietic cells.Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.Perforin: structure, function, and role in human immunopathology.Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions.Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Endocytosing the death sentenceGranzyme B: a natural born killer.Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells.Consensus nomenclature for CD8(+) T cell phenotypes in cancerPrimary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis.Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells.Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic beta-cellsA clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.Human NK cell lytic granules and regulation of their exocytosisStrategies for carbohydrate recognition by the mannose 6-phosphate receptors.Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.The possible role of granzyme B in the pathogenesis of chronic obstructive pulmonary disease.The battlefield of perforin/granzyme cell death pathways.Expression of multiple granzymes by cytotoxic T lymphocyte implies that they activate diverse apoptotic pathways in target cells.The biogenesis of lysosomes and lysosome-related organellesIdentification of residues essential for carbohydrate recognition by the insulin-like growth factor II/mannose 6-phosphate receptor.Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F.TGN exit of the cation-independent mannose 6-phosphate receptor does not require acid hydrolase binding.Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes.Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement.Cell binding, internalization and cytotoxic activity of human granzyme B expressed in the yeast Pichia pastoris.Natural killer cell activity and dysfunction in Hermansky-Pudlak syndrome.Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C.The biogenesis of the MHC class II compartment in human I-cell disease B lymphoblasts.
P2860
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P2860
Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Granzymes A and B are targeted ...... mannose-6-phosphate receptor.
@en
Granzymes A and B are targeted ...... mannose-6-phosphate receptor.
@nl
type
label
Granzymes A and B are targeted ...... mannose-6-phosphate receptor.
@en
Granzymes A and B are targeted ...... mannose-6-phosphate receptor.
@nl
prefLabel
Granzymes A and B are targeted ...... mannose-6-phosphate receptor.
@en
Granzymes A and B are targeted ...... mannose-6-phosphate receptor.
@nl
P2860
P356
P1476
Granzymes A and B are targeted ...... mannose-6-phosphate receptor.
@en
P2093
P2860
P304
P356
10.1083/JCB.120.4.885
P407
P577
1993-02-01T00:00:00Z