Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.
about
Targeting the ubiquitin pathway for cancer treatmentSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamTherapeutic considerations for Mdm2: not just a one trick ponyDesign, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.The central region of HDM2 provides a second binding site for p53.Cytotoxic effect of a non-peptidic small molecular inhibitor of the p53-HDM2 interaction on tumor cells.Inhibiting the p53-MDM2 interaction: an important target for cancer therapy.Peptides with anticancer use or potential.Targeting protein-protein interfaces using macrocyclic peptides.Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.Novel cancer therapy by reactivation of the p53 apoptosis pathway.Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interactionTargeting the p53-MDM2 interaction to treat cancer.Novel activators of the tumour suppressor p53.Molecular neuro-oncology and the development of targeted therapeutic strategies for brain tumors. Part 4: p53 signaling pathway.Chemical approaches to the discovery and development of cancer therapies.The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin.Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structuresProtein-protein interactions as targets for small-molecule therapeutics in cancer.Synthesis of the Chlorofusin Cyclic PeptideEvaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues.Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53-HDM2 Protein-Protein Interaction.Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53.The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interactionA gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulansNPCARE: database of natural products and fractional extracts for cancer regulation.Highly N-methylated linear peptides produced by an atypical sponge-derived Acremonium sp.Patented small molecule inhibitors of p53-MDM2 interaction.Inhibitors of MDM2 and MDMX: a structural perspective.Discovery of microbial natural products by activation of silent biosynthetic gene clusters.Solution structure of the C4 zinc finger domain of HDM2.Anoikis triggers Mdm2-dependent p53 degradation.A divergent asymmetric approach to aza-spiropyran derivative and (1S,8aR)-1-hydroxyindolizidine.Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: highly enantioselective synthesis of chiral N,O-ketals.Redox properties of Cys2His2 and Cys4 zinc fingers determined by electrospray ionization mass spectrometry.Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine
P2860
Q26866185-C8445FED-5C83-49FF-A95C-2FD0F06A6BBCQ29617758-E6570C91-2C47-4F32-A050-5CC6763BF49CQ30380490-E9323F43-83CC-4331-B58B-60740C359B1DQ33424678-D9FB3CFC-8873-4DD9-826E-F445DDBB04CCQ34335012-B1C6CB53-F001-47E1-9BD2-391EDFAC0FF0Q35010309-E52D2169-DFC4-473B-879E-40D279519DB1Q35058579-16C7DCC0-755E-4581-8342-1DC383DC580DQ35167010-9184C129-174A-4CA4-A11A-192CE9F48A3DQ35558196-73951599-6726-4CFE-AEEF-A3752E66FEA5Q35559055-5FE11A14-FB1E-408F-B189-DC05BBF5C54EQ35597613-A650B6F8-2ADF-44EF-AFBE-58B4D130585EQ35643329-AB2571C2-D3DA-46D9-BCC4-8B6553920813Q35903526-86A29E44-9B9C-4595-8A9B-ADC80C478AABQ35939102-FBCBAC5E-8643-4EF2-9478-6583CE503179Q36066191-16AB81B4-BC6F-44C7-9948-17E53329BFE1Q36085630-E7696461-5F9A-49EB-AB9D-34BE95E3C2F2Q36568401-C1566F3C-93EB-465A-8A77-1C086B2F0F42Q36865738-F8349D86-EAF5-42D7-A99B-144820D6894EQ36983259-C8542B8A-D595-4DE0-AD39-786901EF8396Q37114139-3E8AD44E-3D84-496B-AB89-2592AF8F0C1DQ37149477-881605FC-8341-4EDC-B0D6-14AB5F4DFEF0Q37231202-BCC86E7C-D77F-40B8-B6F7-48B3A5D7A0CFQ37262594-1B51C610-FFE4-4EB0-8E46-022EF7CF3CCFQ37283483-67D899F7-14AD-4FE9-AE9E-8696D1DC39D5Q37286347-F8A2B741-F67D-4EA4-BBD2-8745DA3A51CFQ37395784-4DAB1973-BF07-4632-BB79-23CABF14A0FEQ37608107-B9A4B182-ADFF-4195-89D9-7E51DFD8F125Q37678111-9E4D0223-9D52-4F4A-9B7E-CCA6C5C6A3C8Q37689194-E3DF75A5-6F89-4593-974C-EB00EC678CF4Q37855826-6CA02720-7856-4400-BB61-CE0570821182Q38539563-8E13ADA4-8088-4D26-99F6-B43390A08C8AQ42032031-819B5C41-EF2A-404D-A653-2ACDDC2E8B66Q42423622-1DF094F6-D0A4-490A-A072-AD51B0968CA9Q42953606-31CA89D8-A823-468C-991B-87D0D8956172Q51301238-88BAB84C-6D95-4AB2-B86B-87EACB9FF7D8Q55229564-A0AB9147-3180-4826-B469-82AEFFEEB5DBQ57496075-E01DB5A1-8339-4991-A84F-7D865F6BD7F6
P2860
Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Isolation and structure elucid ...... antagonist from a Fusarium sp.
@en
Isolation and structure elucid ...... antagonist from a Fusarium sp.
@nl
type
label
Isolation and structure elucid ...... antagonist from a Fusarium sp.
@en
Isolation and structure elucid ...... antagonist from a Fusarium sp.
@nl
prefLabel
Isolation and structure elucid ...... antagonist from a Fusarium sp.
@en
Isolation and structure elucid ...... antagonist from a Fusarium sp.
@nl
P2093
P356
P1476
Isolation and structure elucid ...... antagonist from a Fusarium sp.
@en
P2093
C McNicholas
D H Williams
S Grüschow
S J Duncan
S K Wrigley
P304
P356
10.1021/JA002940P
P407
P577
2001-01-01T00:00:00Z