The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.
about
Tubulin-interactive natural products as anticancer agentsAntimitotic drugs in the treatment of cancerStabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option?Laulimalide induces dose-dependent modulation of microtubule behaviour in the C. elegans embryoStructural basis of microtubule stabilization by laulimalide and peloruside ATaxol crystals can masquerade as stabilized microtubulesThe Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments.Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubulesPotentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing miceMechanisms of Taxol resistance related to microtubules.A selective account of effective paradigms and significant outcomes in the discovery of inspirational marine natural products.Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.Microtubule-stabilizing drugs from marine sponges: focus on peloruside A and zampanolideHarnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.Enantioselective syntheses of the proposed structures of cytotoxic macrolides iriomoteolide-1a and -1b.Capturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine.The assembly-inducing laulimalide/peloruside a binding site on tubulin: molecular modeling and biochemical studies with [³H]peloruside A.Microtubule-stabilizing agents based on designed laulimalide analogues.Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.Role of the cytoskeleton in formation and maintenance of angiogenic sproutsLaulimalide and peloruside A inhibit mitosis of Saccharomyces cerevisiae by preventing microtubule depolymerisation-dependent steps in chromosome separation and nuclear positioning.Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes.Mutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding.Conformation-activity relationships of polyketide natural products.Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.Low-dose laulimalide represents a novel molecular probe for investigating microtubule organizationTotal synthesis of laulimalide: synthesis of the northern and southern fragmentsA unique mode of microtubule stabilization induced by peloruside AAnticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Total Synthesis of Potent Antitumor Macrolide, (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy.An overview of tubulin inhibitors that interact with the colchicine binding siteFunction-oriented synthesis: biological evaluation of laulimalide analogues derived from a last step cross metathesis diversification strategy.2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypesTaccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.Sponge-derived fijianolide polyketide class: further evaluation of their structural and cytotoxicity properties.Microtubule stabilising agents for cancer chemotherapy.Targeting microtubules by natural agents for cancer therapy.Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM StructuresNew microtubule-inhibiting anticancer agents.The medicinal potential of promising marine macrolides with anticancer activity.
P2860
Q24650163-A84AF5EF-A8EE-4A06-8CF1-EDAD206C453FQ26777317-EB04445C-9D4B-49C2-9DB6-A87FC13579F6Q26781365-68FCE3D2-1AC5-4E5E-8967-B4C6CC5FF16FQ27309120-5A46E9CB-8BC0-49CA-9199-80AC7ED49D3EQ27689025-23710487-3921-43A2-83B4-745FDD939348Q28471966-14F2F6FF-9996-4B0E-9F6A-8101E6E78340Q30368446-4B7973F8-7A79-43BA-901D-0791A824E13BQ30518054-128EDEA9-8199-4FDE-B42F-EAD95EEBC2E4Q33688024-99FEDBA5-1A01-45CE-9C2D-AE3E0BC8F722Q33688044-4849376F-73F7-4F2C-BE49-C7BC1E498072Q33721944-1979BB8E-2253-443B-B6F4-CE829C5FC4CAQ33834080-4EFE5103-8A60-460B-86B1-D3118A72A0F0Q33837001-4B753159-2A82-4AA8-8790-7A4CA99F91EDQ33870886-94553E30-A716-4302-9EFD-96573EAE6C77Q34059908-E89C388B-C22E-463E-A42B-01E369F38C66Q34361292-6FFCDE2D-8EA5-423B-8038-237ECD9411A5Q34374214-5454E66C-362E-49E2-8624-5ECC09130AD5Q34515802-10B3D28B-203D-488F-B3B9-F82C2F934E3CQ34719865-BCB720BB-28E0-4323-812B-F83C276D978DQ34829230-5B606152-CEB1-462F-BD07-D185F79D5807Q34993896-44C35FE2-DF57-49A1-8C2C-FD9D62BEE00BQ35172172-D594FAC1-CC06-4F11-9909-6E1C2399EB2DQ35600753-E28FFF35-B321-4614-A9AF-D589BEE6AEB1Q35645437-F6D43FA4-EF57-4698-B224-F548924FF02CQ35664859-0903B9A5-BDEA-46FA-B05E-9FD6F989F888Q36235535-B5009C76-9D7B-4494-B6C8-FEE5FEA92F6AQ36452821-028F31E9-4FB3-4A5E-8392-7FF997698805Q36740574-6684EA5B-D858-44DC-9CB8-11A04B889B21Q36772390-CF69DBD4-B1C7-4FD2-BCDB-4114E8859D3CQ36777422-4460455C-D01D-46C0-AC00-1315F2D88FE9Q36885540-83A664DE-622B-4D5D-AF9D-A4F388F7E475Q37178856-D77C15C6-BD12-4A2F-A1D3-A5F9016EEA44Q37323043-6912C3D3-C732-42B4-8B12-716E96505F5AQ37339521-BCEA8E9C-1E25-46E2-895D-F68968B4BE1CQ37409426-C3F7F45C-C7B1-4380-9AFB-5A21C3019381Q37481355-4F677848-9324-4E4A-BC6A-EEEEE0D045CBQ37623838-7B61A1A7-28AB-4932-96E7-2FD7CD095680Q37666218-D03F83DD-C2BD-44EC-ADF9-71E4BFA059D0Q37689138-DDBF343F-B4DC-4C95-A27E-FFCE39690AA1Q37837738-094603FA-6D9B-4535-A4BA-DFABDAFC193E
P2860
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
The microtubule stabilizing ag ...... s epoxide moiety for activity.
@en
The microtubule stabilizing ag ...... s epoxide moiety for activity.
@nl
type
label
The microtubule stabilizing ag ...... s epoxide moiety for activity.
@en
The microtubule stabilizing ag ...... s epoxide moiety for activity.
@nl
prefLabel
The microtubule stabilizing ag ...... s epoxide moiety for activity.
@en
The microtubule stabilizing ag ...... s epoxide moiety for activity.
@nl
P2093
P50
P356
P1433
P1476
The microtubule stabilizing ag ...... ts epoxide moiety for activity
@en
P2093
Arun K Ghosh
Aurora O'Brate
Donald E Pryor
Ernest Hamel
Geoffrey Bilcer
M Katherine Jung
Mikio Kabaki
Yuefang Wang
P304
P356
10.1021/BI020211B
P407
P577
2002-07-01T00:00:00Z