Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore.
about
Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-)Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.Modeling the conformational changes underlying channel opening in CFTRCFTR channel pharmacology: novel pore blockers identified by high-throughput screening.Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.Divergent CFTR orthologs respond differently to the channel inhibitors CFTRinh-172, glibenclamide, and GlyH-101Mechanism of chloride permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.Insight in eukaryotic ABC transporter function by mutation analysis.Voltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel.Functional architecture of the CFTR chloride channel.Architecture and functional properties of the CFTR channel pore.Relative movements of transmembrane regions at the outer mouth of the cystic fibrosis transmembrane conductance regulator channel pore during channel gatingPseudohalide anions reveal a novel extracellular site for potentiators to increase CFTR function.Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore.State-dependent access of anions to the cystic fibrosis transmembrane conductance regulator chloride channel pore.On the origin of asymmetric interactions between permeant anions and the cystic fibrosis transmembrane conductance regulator chloride channel pore.Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Coupled movement of permeant and blocking ions in the CFTR chloride channel pore.The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor.Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore.Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.Determination of the functional unit of the cystic fibrosis transmembrane conductance regulator chloride channel. One polypeptide forms one pore.Conformational changes in a pore-lining helix coupled to cystic fibrosis transmembrane conductance regulator channel gating.Evidence that extracellular anions interact with a site outside the CFTR chloride channel pore to modify channel properties.Location of a permeant anion binding site in the cystic fibrosis transmembrane conductance regulator chloride channel pore.
P2860
Q28941777-68118B7D-D1E2-4723-990F-702B7D25F5C3Q30372632-159D70F3-7648-4C1F-8BF6-10E3BC40B69FQ35005061-925F065E-65E6-476D-B40F-88B9960A7FBEQ35847415-65E9CA51-E047-49AE-ACBB-460FED84F8F5Q35862414-DA6237F5-6783-4A84-84F9-A56510164FC6Q35895699-2039F88C-5CA0-429C-A3F1-A2138A5026C9Q36255649-E830D903-4E06-450B-BEA5-4AA9103A1D93Q36379776-C8224946-D9DD-4066-8EB6-8B160CBC46A7Q36436627-ED836483-94C4-4DE8-A6E1-5C00F3C3CD67Q38171539-03FC0C85-3302-4B98-8EF5-BD82C310D9DCQ38971502-10E5F88B-2905-4FAC-BCCC-96D93713B128Q39306475-BB0BD4B3-44F1-4A5A-84B3-0D6EFBED8A8EQ39345267-2E7DBCA7-22BC-4E3A-B8BD-37818075C180Q39388172-266E8679-BF75-4300-9C2E-A8A3533A0C48Q40029008-01C66B9D-203E-41F4-8D35-59244A116479Q40201664-365043DE-044A-47BD-A7A5-1D8BEFFB3FE4Q40500058-E90E7864-7C04-46B5-BACA-9CCCC3E4BD03Q40658013-C105D5F2-8770-4D26-8211-6D793F06AC93Q41580343-E00411DE-FB8C-4502-869F-F37888AE699CQ42024754-97B79BD4-FD19-4BEB-AFC2-C11E6799B5DDQ42861207-D6A469BB-D9A7-4EBE-B44C-54000B0B6609Q45124216-22B7EBC7-6128-4797-9259-8A5713D6D6D5Q46868628-1CFDB864-A832-4690-9D45-A0A4FB90FE8EQ47781167-FDA7F08F-715B-43FC-88DA-62C695E9DDCEQ51744580-4635EA2F-D7DE-4AEB-9926-AE3F6A567FED
P2860
Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
Molecular determinants and rol ...... he CFTR chloride channel pore.
@en
Molecular determinants and rol ...... he CFTR chloride channel pore.
@nl
type
label
Molecular determinants and rol ...... he CFTR chloride channel pore.
@en
Molecular determinants and rol ...... he CFTR chloride channel pore.
@nl
prefLabel
Molecular determinants and rol ...... he CFTR chloride channel pore.
@en
Molecular determinants and rol ...... he CFTR chloride channel pore.
@nl
P2860
P1476
Molecular determinants and rol ...... he CFTR chloride channel pore.
@en
P2093
Xiandi Gong
P2860
P304
P356
10.1113/JPHYSIOL.2002.038232
P407
P577
2003-04-04T00:00:00Z