Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).
about
Antiviral action of the tumor suppressor ARFOncolytic Replication of E1b-Deleted AdenovirusesRal GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformationA dynamical systems model for combinatorial cancer therapy enhances oncolytic adenovirus efficacy by MEK-inhibitionReplicating adenoviruses that target tumors with constitutive activation of the wnt signaling pathwayOncolytic virotherapy: molecular targets in tumor-selective replication and carrier cell-mediated delivery of oncolytic virusesHeterochromatin silencing of p53 target genes by a small viral protein.ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus.Clinical research results with dl1520 (Onyx-015), a replication-selective adenovirus for the treatment of cancer: what have we learned?Does the antitumor adenovirus ONYX-015/dl1520 selectively target cells defective in the p53 pathway?Replication-selective oncolytic adenoviruses: virotherapy aimed at genetic targets in cancer.Replication-selective virotherapy for cancer: Biological principles, risk management and future directions.Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway.Oncolytic virotherapy for cancer with the adenovirus dl1520 (Onyx-015): results of phase I and II trials.Comparative effect of oncolytic adenoviruses with E1A-55 kDa or E1B-55 kDa deletions in malignant gliomas2-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells.Active targeting of RGD-conjugated bioreducible polymer for delivery of oncolytic adenovirus expressing shRNA against IL-8 mRNA.Oncolytic adenoviruses for treatment of brain tumours.Intravascular adenoviral agents in cancer patients: lessons from clinical trials.MDM2 promotes ubiquitination and degradation of MDMXpH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesisGene therapy progress and prospects: cancer gene therapy using tumour suppressor genes.Tissue-specific promoters for cancer gene therapy.A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation.The use of gene therapy in cancer research and treatment.An attenuated adenovirus, ONYX-015, as mouthwash therapy for premalignant oral dysplasia.Replication-selective oncolytic viruses in the treatment of cancer.Conditionally replicating adenoviruses for cancer treatment.The tumor suppressor gene TP53: implications for cancer management and therapy.Gene- and immunotherapy for hepatocellular carcinoma.The feasibility of gene therapy in the treatment of head and neck cancerKilling of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia proteinGene therapy for bladder cancer using E1B-55 kD-deleted adenovirus in combination with adenoviral vector encoding plasminogen kringles 1-5.Armed replicating adenoviruses for cancer virotherapy.Adenoviral vector-based strategies for cancer therapy.Emerging roles of p53 and other tumour-suppressor genes in immune regulationOncolytic adenoviruses expressing interleukin: a novel antitumour approach.Oncolytic viruses in the treatment of cancer: a review of current strategies.Analyses of single-amino-acid substitution mutants of adenovirus type 5 E1B-55K proteinEvidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes.
P2860
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P2860
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520 (ONYX-015).
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh-hant
name
Loss of p14ARF in tumor cells ...... irus mutant dl1520 (ONYX-015).
@en
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520
@nl
type
label
Loss of p14ARF in tumor cells ...... irus mutant dl1520 (ONYX-015).
@en
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520
@nl
prefLabel
Loss of p14ARF in tumor cells ...... irus mutant dl1520 (ONYX-015).
@en
Loss of p14ARF in tumor cells facilitates replication of the adenovirus mutant dl1520
@nl
P2093
P2860
P356
P1433
P1476
Loss of p14ARF in tumor cells ...... virus mutant dl1520 (ONYX-015)
@en
P2093
C H Biederer
E M Lipner
F McCormick
P2860
P2888
P304
P356
10.1038/80466
P407
P577
2000-10-01T00:00:00Z
P5875
P6179
1046045283