Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals.
about
RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteinsSUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.XRCC4's interaction with XLF is required for coding (but not signal) end joiningA deletion map of the human immunoglobulin heavy chain variable regionRecombinational DNA Repair in Cancer and Normal Cells: The Challenge of Functional AnalysisA functional analysis of the spacer of V(D)J recombination signal sequencesArtemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcsAnalysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpointsKu70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombinationConservation of sequence in recombination signal sequence spacersThe response to and repair of RAG-mediated DNA double-strand breaksMechanistic constraints on diversity in human V(D)J recombinationMolluscan mobile elements similar to the vertebrate Recombination-Activating GenesHuman RAG mutations: biochemistry and clinical implicationsERCC1-XPF endonuclease facilitates DNA double-strand break repairLate embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IVExpression and V(D)J recombination activity of mutated RAG-1 proteinsDefective DNA repair and increased genomic instability in Artemis-deficient murine cellsA new vector for cloning large eukaryotic DNA segments in Escherichia coli.In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.Independent recruitment of Igh alleles in V(D)J recombination.Joining of linear plasmid DNA is reduced and error-prone in Bloom's syndrome cells.T-cell receptor gene rearrangements in functional T-cell clones from severe combined immune deficient (scid) mice: reversion of the scid phenotype in individual lymphocyte progenitors.A conserved sequence in the T-cell receptor beta-chain promoter regionBoth V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.Requirement for ubiquitin conjugation and 26S proteasome activity at an early stage in V(D)J recombinationEquine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.Functional analysis of coordinated cleavage in V(D)J recombination.Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination.Dual role of RAG2 in V(D)J recombination: catalysis and regulation of ordered Ig gene assembly.V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMPImmunoglobulin V gene replacement is caused by the intramolecular DNA deletion mechanismEnumeration and characterization of DJH structures in mouse fetal liver.Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity.Mutations in conserved regions of the predicted RAG2 kelch repeats block initiation of V(D)J recombination and result in primary immunodeficienciesRag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination.Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AXAn autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.
P2860
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P2860
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh
1987年學術文章
@zh-hant
name
Extrachromosomal DNA substrate ...... deletion at immunoglobulin V-
@nl
Extrachromosomal DNA substrate ...... bulin V-(D)-J joining signals.
@en
type
label
Extrachromosomal DNA substrate ...... deletion at immunoglobulin V-
@nl
Extrachromosomal DNA substrate ...... bulin V-(D)-J joining signals.
@en
prefLabel
Extrachromosomal DNA substrate ...... deletion at immunoglobulin V-
@nl
Extrachromosomal DNA substrate ...... bulin V-(D)-J joining signals.
@en
P2093
P1433
P1476
Extrachromosomal DNA substrate ...... bulin V-(D)-J joining signals.
@en
P2093
P304
P356
10.1016/0092-8674(87)90615-5
P407
P577
1987-06-01T00:00:00Z