Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains. - Wikidata - awgldk - TriplyDB

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains.

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains.

http://www.wikidata.org/entity/Q45271574

about

Parkin ubiquitinates and promotes the degradation of RanBP2 Autoregulation of Parkin activity through its ubiquitin-like domain The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection NUB1 suppresses the formation of Lewy body-like inclusions by proteasomal degradation of synphilin-1 Parkin-mediated monoubiquitination of the PDZ protein PICK1 regulates the activity of acid-sensing ion channels Parkin Regulation and Neurodegenerative Disorders RBR E3 ubiquitin ligases: new structures, new insights, new questions Mitochondrial dysfunction and oxidative stress in Parkinson's disease A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease 14-3-3eta is a novel regulator of parkin ubiquitin ligase.Aggresome formation and neurodegenerative diseases: therapeutic implications Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6 Role of the ubiquitin proteasome system in Parkinson's disease.Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63 Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination.Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice.Generation and physiological roles of linear ubiquitin chains.Following Ariadne's thread: a new perspective on RBR ubiquitin ligases Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity.Versatile roles of k63-linked ubiquitin chains in trafficking.Proteasome inhibition promotes Parkin-Ubc13 interaction and lysine 63-linked ubiquitination Parkin mediates the degradation-independent ubiquitination of Hsp70 Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling Mitochondrial dynamics and Parkinson's disease: focus on parkin.Aspects of innate immunity and Parkinson's disease.Recessive Parkinson's disease.Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversies.The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases.Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.The E3 ubiquitin ligase XIAP restricts Anaplasma phagocytophilum colonization of Ixodes scapularis ticks The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics.Infection-derived lipids elicit an immune deficiency circuit in arthropods.The role of parkin in familial and sporadic Parkinson's disease.Lentiviral vector-mediated gene transfer and RNA silencing technology in neuronal dysfunctions.Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy?Parkin, A Top Level Manager in the Cell's Sanitation Department.

P2860

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P2860

Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains.

http://www.wikidata.org/entity/Q45271574

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

@zh-hans

2005年学术文章

@zh-my

2005年学术文章

@zh-sg

2005年學術文章

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2005年學術文章

@zh

2005年學術文章

@zh-hant

name

Alpha-synuclein and parkin con ...... -linked multiubiquitin chains.

@en

Alpha-synuclein and parkin con ...... -linked multiubiquitin chains.

@nl

type

label

Alpha-synuclein and parkin con ...... -linked multiubiquitin chains.

@en

Alpha-synuclein and parkin con ...... -linked multiubiquitin chains.

@nl

prefLabel

Alpha-synuclein and parkin con ...... -linked multiubiquitin chains.

@en

Alpha-synuclein and parkin con ...... -linked multiubiquitin chains.

@nl

P1433

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P1433

Journal of Biological Chemistry

P1476

Alpha-synuclein and parkin con ...... -linked multiubiquitin chains.

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P2093

Ellen W Doss-Pepe

http://www.w3.org/2001/XMLSchema#string

Kiran Madura

http://www.w3.org/2001/XMLSchema#string

Li Chen

http://www.w3.org/2001/XMLSchema#string

P2860

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells.

Modulation of dopamine transporter function by alpha-synuclein is altered by impairment of cell adhesion and by induction of oxidative stress

Recognition of the polyubiquitin proteolytic signal

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies.

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16619-16624

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scholarly article

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10.1074/JBC.M413591200

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17

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280

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2005-02-16T00:00:00Z

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15718234

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P921