Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.
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Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytesDefective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicityGene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass.Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes.Free fatty acids block glucose-induced β-cell proliferation in mice by inducing cell cycle inhibitors p16 and p18Islet β cell mass in diabetes and how it relates to function, birth, and death.In vivo beta-cell imaging with VMAT 2 ligands--current state-of-the-art and future perspective.FoxO1 Deacetylation Decreases Fatty Acid Oxidation in β-Cells and Sustains Insulin Secretion in Diabetes.Peroxisome proliferator-activated receptor γ (PPARγ) and its target genes are downstream effectors of FoxO1 protein in islet β-cells: mechanism of β-cell compensation and failure.PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation.Body mass index and outcomes from pancreatic resection: a review and meta-analysis.Shaping and preserving β-cell identity with microRNAs.Mechanisms of β-cell functional adaptation to changes in workloadAdipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion.Metabolic inflexibility impairs insulin secretion and results in MODY-like diabetes in triple FoxO-deficient mice.Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes.β-cell metabolic alterations under chronic nutrient overload in rat and human islets.Voluntary running exercise prevents β-cell failure in susceptible islets of the Zucker diabetic fatty rat
P2860
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P2860
Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass.
description
2009 nî lūn-bûn
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name
Islet beta cell failure in the ...... s or a falling beta cell mass.
@en
Islet beta cell failure in the ...... s or a falling beta cell mass.
@nl
type
label
Islet beta cell failure in the ...... s or a falling beta cell mass.
@en
Islet beta cell failure in the ...... s or a falling beta cell mass.
@nl
prefLabel
Islet beta cell failure in the ...... s or a falling beta cell mass.
@en
Islet beta cell failure in the ...... s or a falling beta cell mass.
@nl
P2093
P1433
P1476
Islet beta cell failure in the ...... s or a falling beta cell mass.
@en
P2093
M G Latour
M Peshavaria
S R Murthy Madiraju
T L Jetton
V Delghingaro-Augusto
P2888
P304
P356
10.1007/S00125-009-1317-8
P577
2009-03-18T00:00:00Z