Somatic hypermutation in the heavy chain locus correlates with transcription.
about
Altered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminationsActivation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseGenetic manipulation of an exogenous non-immunoglobulin protein by gene conversion machinery in a chicken B cell lineKinetic models reveal the in vivo mechanisms of mutagenesis in microbes and manRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationAID targeting is dependent on RNA polymerase II pausing.RNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeFirst AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodiesDisruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast GenesDifferent mismatch repair deficiencies all have the same effects on somatic hypermutation: intact primary mechanism accompanied by secondary modificationsAID and Apobec3G haphazard deamination and mutational diversityEffects of prostaglandin E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansionEctopic expression of AID in a non-B cell line triggers A:T and G:C point mutations in non-replicating episomal vectors.Impact of phosphorylation and phosphorylation-null mutants on the activity and deamination specificity of activation-induced cytidine deaminase.A coming-of-age story: activation-induced cytidine deaminase turns 10.The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.The reverse transcriptase model of somatic hypermutationTranscription, beta-like DNA polymerases and hypermutationComplex regulation of somatic hypermutation by cis-acting sequences in the endogenous IgH gene in hybridoma cellsVariable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombinationRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodiesLinking class-switch recombination with somatic hypermutation.AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.Mechanisms of chromosomal translocations in B cell lymphomas.Negative regulation of activation-induced cytidine deaminase in B cellsThe connection between transcription and genomic instability.AID-initiated DNA lesions are differentially processed in distinct B cell populations.Targeting of somatic hypermutation.B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.AID and mismatch repair in antibody diversification.Cis-regulatory elements and epigenetic changes control genomic rearrangements of the IgH locus.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.What role for AID: mutator, or assembler of the immunoglobulin mutasome?
P2860
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P2860
Somatic hypermutation in the heavy chain locus correlates with transcription.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Somatic hypermutation in the heavy chain locus correlates with transcription.
@en
Somatic hypermutation in the heavy chain locus correlates with transcription.
@nl
type
label
Somatic hypermutation in the heavy chain locus correlates with transcription.
@en
Somatic hypermutation in the heavy chain locus correlates with transcription.
@nl
prefLabel
Somatic hypermutation in the heavy chain locus correlates with transcription.
@en
Somatic hypermutation in the heavy chain locus correlates with transcription.
@nl
P1433
P1476
Somatic hypermutation in the heavy chain locus correlates with transcription.
@en
P2093
P304
P356
10.1016/S1074-7613(00)80592-0
P407
P577
1998-07-01T00:00:00Z