Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels.
about
Rac GTPase signaling through the PP5 protein phosphataseA recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channelsStructure of the C-terminal region of an ERG channel and functional implicationsRapid signaling at the plasma membrane by a nuclear receptor for thyroid hormoneAbsence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methodsAntiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG K+ channels in parkinsonian discharges.Functional evolution of Erg potassium channel gating reveals an ancient origin for IKrRedox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation.High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance.Mapping the receptor site for ergtoxin, a specific blocker of ERG channels.Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels.Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel.The Eag domain regulates the voltage-dependent inactivation of rat Eag1 K+ channels.hERG potassium channel gating is mediated by N- and C-terminal region interactionsInhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241.In vitro cardiovascular effects of dihydroartemisin-piperaquine combination compared with other antimalarialsEAG2 potassium channel with evolutionarily conserved function as a brain tumor target.Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes.Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels.Extracellular sodium interacts with the HERG channel at an outer pore site.Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channels.Gating charges in the activation and inactivation processes of the HERG channelMolecular mechanisms for drug interactions with hERG that cause long QT syndrome.The eag domain regulates hERG channel inactivation gating via a direct interaction.The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity.hERG gating microdomains defined by S6 mutagenesis and molecular modeling.Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome.Arrhythmic risk biomarkers for the assessment of drug cardiotoxicity: from experiments to computer simulations.Revealing the structural basis of action of hERG potassium channel activators and blockers.HERG potassium channel regulation by the N-terminal eag domain.The enigmatic cytoplasmic regions of KCNH channels.hERG subunit composition determines differential drug sensitivity.Molecular Pathophysiology of Congenital Long QT Syndrome.Cyamemazine metabolites: effects on human cardiac ion channels in-vitro and on the QTc interval in guinea pigs.Differential effects of amino-terminal distal and proximal domains in the regulation of human erg K(+) channel gating.Functional characterization of ether-à-go-go-related gene potassium channels in midbrain dopamine neurons - implications for a role in depolarization block.Na+ permeation and block of hERG potassium channels.Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs.
P2860
Q24546372-AE713107-1ACA-4CA4-BAA1-7E79E2CEEAE6Q24655800-DCC7B5CA-65EB-40EA-9E4C-5C7A879D3541Q27678809-39759C0A-CBEC-410E-8362-D15A91F67371Q28303035-34DE63B2-EEB0-4A34-9E45-9B6DDB2D19D0Q28591022-B6BE0ED2-B7FF-419B-91C1-05C90FA2B497Q29994716-0C107060-185A-429B-8C67-52B2F96BED2BQ30576425-CA22A7B0-E31D-412F-BAC3-B617906F4F5AQ31387270-CA83617D-3FF6-4866-B210-B970E7BDDBC2Q33165850-72FFAEF9-674A-4528-82D7-167A48DF98F4Q34106481-B7C25ABD-8390-4804-9C13-B8D8AC621C1AQ34156425-4943C0EB-23E1-4717-B8AB-3B111F4111F4Q34170649-CD689516-226B-4600-A001-2D7B05DC9463Q34379526-F532D010-7101-4936-B0D5-6F0DFAF6809BQ34618908-0140DA0F-27FD-4A93-A7A5-ABC52A544B0CQ35044882-C4AA43B4-16D2-4BEF-86BB-371D47F93394Q36018689-AFC483D2-A43D-4CAD-87B7-C9B9C9DEC0E4Q36266346-A8801423-EEE0-42A0-932A-CB287F24CE5BQ36412212-32953281-4F17-4DBD-8F4B-918DB65C8185Q36412430-E2555B38-4AF9-40F3-81CB-92B1AED139BEQ36436152-CFF6E976-1795-442A-9EF2-83947328E726Q36436477-612068C5-B3A4-454F-817E-C713A17DC3A2Q36442897-AEA3DB49-8DE0-4257-B734-18311F7D006CQ36445757-CB28F0ED-B8C9-42C7-ABEF-409CCFB2627EQ36545039-D2C6F8B8-A083-446A-A11B-836FEF51F2B6Q36568494-45F54E80-2766-45C8-926C-F7F1676378F5Q36936368-EC95D8E1-7FF7-4ED3-9ED9-C6E7C70D4F8BQ36946670-F877E815-06CA-4DD2-BD52-4EE65A8FB3EDQ37209213-F0E0C6F4-F985-4D37-999B-ABBDD651B9ACQ37385262-2FCF13C8-82B0-4958-9D6A-68A4823BB36CQ37755876-ED152EC2-49CC-488F-8E20-56C4A771921BQ37774138-6C5A3BC5-439E-43AD-AA70-7953C9A40AB5Q38004348-890BF07D-33D2-438D-B96E-7BA7FC6D362FQ38243381-3ED0D60B-EC3D-4EDF-A793-DF20EA2464F5Q38649960-5B305EC6-302B-4B7A-9B29-478D10A45E6FQ38997049-423C9D3F-8C0F-44F7-8629-87A3D46567F7Q39924256-80FA99C6-7612-4B25-98DB-69051CF4A2F6Q40166581-2991475C-F2F6-45F8-A328-8E834B9243F4Q40198714-FD513B39-4CD6-47F9-904A-BC44800B75C9Q40268694-BDC4EFEE-022D-47DC-AC72-5DE58583C332Q41140521-70CAD008-F0C2-4938-ABB2-3BE2D6286F8C
P2860
Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Transfer of rapid inactivation ...... 1 from HERG to M-eag channels.
@en
Transfer of rapid inactivation ...... 1 from HERG to M-eag channels.
@nl
type
label
Transfer of rapid inactivation ...... 1 from HERG to M-eag channels.
@en
Transfer of rapid inactivation ...... 1 from HERG to M-eag channels.
@nl
prefLabel
Transfer of rapid inactivation ...... 1 from HERG to M-eag channels.
@en
Transfer of rapid inactivation ...... 1 from HERG to M-eag channels.
@nl
P2093
P2860
P1476
Transfer of rapid inactivation ...... 1 from HERG to M-eag channels.
@en
P2093
G A Robertson
I M Herzberg
M C Trudeau
P2860
P356
10.1111/J.1469-7793.1998.003BI.X
P407
P478
511 ( Pt 1)
P577
1998-08-01T00:00:00Z