Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells
about
Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndromeDual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleusThe Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalphaBLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediatesCleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalphaThe RecQ DNA helicases in DNA repairMus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cellsRoles of RECQ helicases in recombination based DNA repair, genomic stability and agingA multiprotein nuclear complex connects Fanconi anemia and Bloom syndromeHuman premature aging, DNA repair and RecQ helicasesTelomere and ribosomal DNA repeats are chromosomal targets of the bloom syndrome DNA helicaseThe C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stabilityStructural and functional characterizations reveal the importance of a zinc binding domain in Bloom's syndrome helicaseRecQ helicases in DNA double strand break repair and telomere maintenance.Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonucleaseEsc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae.RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complexLoss of RMI2 Increases Genome Instability and Causes a Bloom-Like SyndromeTopoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.Unwinding protein complexes in ALTernative telomere maintenance.Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges.WRN helicase defective in the premature aging disorder Werner syndrome genetically interacts with topoisomerase 3 and restores the top3 slow growth phenotype of sgs1 top3Mapping the DNA topoisomerase III binding domain of the Sgs1 DNA helicase.Distinct roles of RECQ1 in the maintenance of genomic stability.The HRDC domain of BLM is required for the dissolution of double Holliday junctionsRegulation of BLM Nucleolar LocalizationPhosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line.G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition.Genetic adaptation associated with genome-doubling in autotetraploid Arabidopsis arenosa.Holliday junction-containing DNA structures persist in cells lacking Sgs1 or Top3 following exposure to DNA damage.Sgs1 truncations induce genome rearrangements but suppress detrimental effects of BLM overexpression in Saccharomyces cerevisiae.Top3α is required during the convergent migration step of double Holliday junction dissolution.The mechanism of Mus81-Mms4 cleavage site selection distinguishes it from the homologous endonuclease Rad1-Rad10.RecQ helicases: suppressors of tumorigenesis and premature aging.The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replicationRECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan.
P2860
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P2860
Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells
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2000 nî lūn-bûn
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Association of the Bloom syndr ...... a in somatic and meiotic cells
@ast
Association of the Bloom syndr ...... a in somatic and meiotic cells
@en
Association of the Bloom syndr ...... a in somatic and meiotic cells
@en-gb
Association of the Bloom syndr ...... a in somatic and meiotic cells
@nl
type
label
Association of the Bloom syndr ...... a in somatic and meiotic cells
@ast
Association of the Bloom syndr ...... a in somatic and meiotic cells
@en
Association of the Bloom syndr ...... a in somatic and meiotic cells
@en-gb
Association of the Bloom syndr ...... a in somatic and meiotic cells
@nl
prefLabel
Association of the Bloom syndr ...... a in somatic and meiotic cells
@ast
Association of the Bloom syndr ...... a in somatic and meiotic cells
@en
Association of the Bloom syndr ...... a in somatic and meiotic cells
@en-gb
Association of the Bloom syndr ...... a in somatic and meiotic cells
@nl
P2093
P3181
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P1476
Association of the Bloom syndr ...... a in somatic and meiotic cells
@en
P2093
D B Lombard
F B Johnson
L Guarente
M A Mastrangelo
R A Marciniak
R Jaenisch
P304
P3181
P407
P577
2000-03-01T00:00:00Z