RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex
about
Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediatesThe RecQ DNA helicases in DNA repairMore complexity to the Bloom's syndrome complexRMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stabilityRECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filamentsMus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiaeCrystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complexStructural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesionA screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions.An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomes.Binding and activation of DNA topoisomerase III by the Rmi1 subunit.RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity.Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thalianaRMI1 deficiency in mice protects from diet and genetic-induced obesitySgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break endsTopoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.RecQ helicases: guardian angels of the DNA replication fork.The Arabidopsis BLAP75/Rmi1 homologue plays crucial roles in meiotic double-strand break repair.Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.TOPO3alpha influences antigenic variation by monitoring expression-site-associated VSG switching in Trypanosoma brucei.DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctions.The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance.Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance.Identification of Trypanosoma brucei RMI1/BLAP75 homologue and its roles in antigenic variation.Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3.The role of post-translational modifications in fine-tuning BLM helicase function during DNA repairSlx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4The dissolution of double Holliday junctions.Top3-Rmi1 DNA single-strand decatenase is integral to the formation and resolution of meiotic recombination intermediates.A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.Mining experimental evidence of molecular function claims from the literature.DNA topoisomerase III localizes to centromeres and affects centromeric CENP-A levels in fission yeast.
P2860
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P2860
RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
RMI1/NCE4, a suppressor of gen ...... RecQ helicase/Topo III complex
@ast
RMI1/NCE4, a suppressor of gen ...... RecQ helicase/Topo III complex
@en
RMI1/NCE4, a suppressor of gen ...... ecQ helicase/Topo III complex.
@nl
type
label
RMI1/NCE4, a suppressor of gen ...... RecQ helicase/Topo III complex
@ast
RMI1/NCE4, a suppressor of gen ...... RecQ helicase/Topo III complex
@en
RMI1/NCE4, a suppressor of gen ...... ecQ helicase/Topo III complex.
@nl
prefLabel
RMI1/NCE4, a suppressor of gen ...... RecQ helicase/Topo III complex
@ast
RMI1/NCE4, a suppressor of gen ...... RecQ helicase/Topo III complex
@en
RMI1/NCE4, a suppressor of gen ...... ecQ helicase/Topo III complex.
@nl
P2093
P2860
P50
P921
P3181
P356
P1433
P1476
RMI1/NCE4, a suppressor of gen ...... RecQ helicase/Topo III complex
@en
P2093
Chaoying Zhang
Charles Boone
Greg A Freyer
Lissette Delgado-Cruzata
Pavel Morozov
Ridhdhi Desai
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7600684
P407
P577
2005-06-01T00:00:00Z