A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis
about
Transcription factors in late megakaryopoiesis and related platelet disordersMef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasisMice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet functionCyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation.2-(trimethylammonium)ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34⁺ haematopoietic stem cells.Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation.Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesisHierarchical differentiation of myeloid progenitors is encoded in the transcription factor networkAML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2TAL-1/SCL and its partners E47 and LMO2 up-regulate VE-cadherin expression in endothelial cells.Combinatorial regulation of tissue specification by GATA and FOG factors.NF-E2 overexpression delays erythroid maturation and increases erythrocyte production.Concise review: Blood relatives: formation and regulation of hematopoietic stem cells by the basic helix-loop-helix transcription factors stem cell leukemia and lymphoblastic leukemia-derived sequence 1.Genome-wide identification of TAL1's functional targets: insights into its mechanisms of action in primary erythroid cells.Combined deficiency of PI3KC2α and PI3KC2β reveals a nonredundant role for PI3KC2α in regulating mouse platelet structure and thrombus stability.The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.
P2860
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P2860
A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis
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2006 nî lūn-bûn
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2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
A critical role for the transc ...... n during stress thrombopoiesis
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A critical role for the transc ...... n during stress thrombopoiesis
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A critical role for the transc ...... n during stress thrombopoiesis
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A critical role for the transc ...... n during stress thrombopoiesis
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A critical role for the transc ...... n during stress thrombopoiesis
@ast
A critical role for the transc ...... n during stress thrombopoiesis
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A critical role for the transc ...... n during stress thrombopoiesis
@en-gb
A critical role for the transc ...... n during stress thrombopoiesis
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A critical role for the transc ...... n during stress thrombopoiesis
@ast
A critical role for the transc ...... n during stress thrombopoiesis
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A critical role for the transc ...... n during stress thrombopoiesis
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A critical role for the transc ...... n during stress thrombopoiesis
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A critical role for the transc ...... n during stress thrombopoiesis
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Ashleigh J Clarke
Jessica M Salmon
Julia A Prentice
Mark A Hall
Nicholas J Slater
Stephen M Jane
P2860
P304
P356
10.1182/BLOOD-2006-02-002188
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P577
2006-06-08T00:00:00Z