A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB. - Test2 - elhamkhani - TriplyDB

A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.

A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.

http://www.wikidata.org/entity/Q33515420

about

Potential of apoptotic pathway-targeted cancer therapeutic research: Where do we stand?Overcoming tumor immune evasion with an unique arbovirus Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721 A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)A smac mimetic reduces TNF related apoptosis inducing ligand (TRAIL)-induced invasion and metastasis of cholangiocarcinoma cells Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity.Natural IAP inhibitor Embelin enhances therapeutic efficacy of ionizing radiation in prostate cancer.Impact of hypoxia on the metastatic potential of human prostate cancer cells.Fas death receptor signalling: roles of Bid and XIAP.High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer.IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets.TRAIL-mediated signaling in prostate, bladder and renal cancer.Harnessing the cell death pathway for targeted cancer treatment.IAPs on the move: role of inhibitors of apoptosis proteins in cell migration.Proteomic tools for the characterization of cell death mechanisms in drug discovery.Carbon-ion beams effectively induce growth inhibition and apoptosis in human neural stem cells compared with glioblastoma A172 cells.Rotundarpene prevents TRAIL-induced apoptosis in human keratinocytes by suppressing the caspase-8- and Bid-pathways and the mitochondrial pathway.Menadione induces the formation of reactive oxygen species and depletion of GSH-mediated apoptosis and inhibits the FAK-mediated cell invasion.Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis.Parthenolide induces apoptosis by activating the mitochondrial and death receptor pathways and inhibits FAK-mediated cell invasion.Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation.Brefeldin a induces apoptosis by activating the mitochondrial and death receptor pathways and inhibits focal adhesion kinase-mediated cell invasion.Physiologically based pharmacokinetic and pharmacodynamic modeling of an antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in a mouse xenograft model of human breast cancer.Ethanol promotes cytotoxic effects of tumor necrosis factor-related apoptosis-inducing ligand through induction of reactive oxygen species in prostate cancer cells.18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells.Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins.Guanylate cyclase activator YC-1 enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells via activation of apoptosis-related proteins.Anti-proliferative and pro-apoptotic actions of a novel human and mouse ovarian tumor-associated gene OTAG-12: downregulation, alternative splicing and drug sensitization.Smac mimetic compounds potentiate interleukin-1beta-mediated cell death Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.Differential response of head and neck cancer cell lines to TRAIL or Smac mimetics is associated with the cellular levels and activity of caspase-8 and caspase-10 3,4,5-Tricaffeoylquinic Acid Attenuates TRAIL-induced Apoptosis in Human Keratinocytes by Suppressing Apoptosis-related Protein Activation.Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy.IAP Antagonists Enhance Cytokine Production from Mouse and Human iNKT Cells.

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A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.

http://www.wikidata.org/entity/Q33515420

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

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A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

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A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

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type

label

A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

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A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

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A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

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prefLabel

A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

@ast

A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

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A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

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A Smac-mimetic sensitizes pros ...... ating both IAPs and NF-kappaB.

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Jiqin Lian

http://www.w3.org/2001/XMLSchema#string

Liang Xu

http://www.w3.org/2001/XMLSchema#string

Meilan Liu

http://www.w3.org/2001/XMLSchema#string

Theodore S Lawrence

http://www.w3.org/2001/XMLSchema#string

Wenhua Tang

http://www.w3.org/2001/XMLSchema#string

Yao Dai

http://www.w3.org/2001/XMLSchema#string

Yongming Li

http://www.w3.org/2001/XMLSchema#string

P2860

Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

COMMD proteins, a novel family of structural and functional homologs of MURR1

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Structural basis of IAP recognition by Smac/DIABLO

Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy

Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis

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10.1186/1471-2407-9-392

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