Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay
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DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionAlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein InteractionsInhibitors of human tyrosyl-DNA phospodiesterase (hTdp1) developed by virtual screening using ligand-based pharmacophores.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform.Biochemical assays for the discovery of TDP1 inhibitorsComplementary non-radioactive assays for investigation of human flap endonuclease 1 activity.Managing missing measurements in small-molecule screens.Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitorsTyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.Synthesis and biological evaluation of new fluorinated and chlorinated indenoisoquinoline topoisomerase I poisons.4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.Investigation of the Structure-Activity Relationships of Aza-A-Ring Indenoisoquinoline Topoisomerase I Poisons.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Structure Modeling of Human Tyrosyl-DNA Phosphodiesterase 1 and Screening for Its Inhibitors.Homogeneous assay for evaluation of aptamer-protein interaction.Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecanIdentification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays.Probabilistic Substructure Mining From Small-Molecule Screens.DNA end-processing enzyme polynucleotide kinase as a potential target in the treatment of cancer.TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan.Benchmarking ligand-based virtual High-Throughput Screening with the PubChem database.Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.Studying TDP1 Function in DNA Repair.Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis.Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1)
P2860
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P2860
Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay
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2009 nî lūn-bûn
@nan
2009 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Identification of phosphotyros ...... haScreen high-throughput assay
@ast
Identification of phosphotyros ...... haScreen high-throughput assay
@en
type
label
Identification of phosphotyros ...... haScreen high-throughput assay
@ast
Identification of phosphotyros ...... haScreen high-throughput assay
@en
prefLabel
Identification of phosphotyros ...... haScreen high-throughput assay
@ast
Identification of phosphotyros ...... haScreen high-throughput assay
@en
P2093
P2860
P50
P1476
Identification of phosphotyros ...... haScreen high-throughput assay
@en
P2093
Christophe Marchand
James Inglese
Thomas S Dexheimer
Wendy A Lea
P2860
P304
P356
10.1158/1535-7163.MCT-08-0878
P577
2009-01-01T00:00:00Z