Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil
about
Targeting abnormal DNA repair in therapy-resistant breast cancersDNA glycosylases: in DNA repair and beyondPreclinical study of the DNA repair inhibitor Dbait in combination with chemotherapy in colorectal cancerRole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesThe chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cellsMolecular resistance fingerprint of pemetrexed and platinum in a long-term survivor of mesotheliomaEmbryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stabilityA germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformationOpposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylaseFluoropyrimidine ActivityCRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phaseHistone/protein deacetylase SIRT1 is an anticancer therapeutic target.Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alphaGermline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stressThe hepatitis B virus x protein inhibits thymine DNA glycosylase initiated base excision repairCks overexpression enhances chemotherapeutic efficacy by overriding DNA damage checkpoints.Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.Restriction-modification system with methyl-inhibited base excision and abasic-site cleavage activitiesSynergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells.UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.Gadd45a promotes DNA demethylation through TDG.Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase.Prolonged pemetrexed pretreatment augments persistence of cisplatin-induced DNA damage and eliminates resistant lung cancer stem-like cells associated with EMTMultifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesisGenomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous RecombinationDNA mismatch repair and the DNA damage response.7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase.Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types.Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cellsA comprehensive survey of the mutagenic impact of common cancer cytotoxicsEstablishing a model for assessing DNA damage in murine brain cells as a molecular marker of chemotherapy-associated cognitive impairment.Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase.Clinical Significance and Prognostic Relevance of Microsatellite Instability in Sporadic Colorectal Cancer Patients.
P2860
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P2860
Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Base excision by thymine DNA g ...... cytotoxicity of 5-fluorouracil
@ast
Base excision by thymine DNA g ...... cytotoxicity of 5-fluorouracil
@en
Base excision by thymine DNA g ...... ytotoxicity of 5-fluorouracil.
@nl
type
label
Base excision by thymine DNA g ...... cytotoxicity of 5-fluorouracil
@ast
Base excision by thymine DNA g ...... cytotoxicity of 5-fluorouracil
@en
Base excision by thymine DNA g ...... ytotoxicity of 5-fluorouracil.
@nl
altLabel
Base excision by thymine DNA g ...... cytotoxicity of 5-fluorouracil
@en
prefLabel
Base excision by thymine DNA g ...... cytotoxicity of 5-fluorouracil
@ast
Base excision by thymine DNA g ...... cytotoxicity of 5-fluorouracil
@en
Base excision by thymine DNA g ...... ytotoxicity of 5-fluorouracil.
@nl
P2093
P2860
P50
P3181
P1433
P1476
Base excision by thymine DNA g ...... cytotoxicity of 5-fluorouracil
@en
P2093
David Schuermann
Frauke Focke
Teresa Lettieri
Yusuke Saito
P2860
P3181
P356
10.1371/JOURNAL.PBIO.1000091
P407
P577
2009-04-01T00:00:00Z