Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
about
PINK1 is selectively stabilized on impaired mitochondria to activate ParkinBrain region specific mitophagy capacity could contribute to selective neuronal vulnerability in Parkinson's diseaseParkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondriaUbiquitin is phosphorylated by PINK1 to activate parkinPINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motilityMUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkinMitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagyThe role of oxidative stress in Parkinson's diseaseHigh-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagyPINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fissionLeucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's diseaseLoss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxiaBroad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagyAutophagy, mitochondria and oxidative stress: cross-talk and redox signallingCurcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryMitochondrial dysfunction in Parkinson's diseaseRedox mechanisms in age-related lung fibrosisParkinson's Disease: The Mitochondria-Iron LinkThe Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative DiseasesRegulation of mitochondrial functions by protein phosphorylation and dephosphorylationAlterations in Mitochondrial Quality Control in Alzheimer's DiseaseElectron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsOxidative stress and Parkinson's diseaseMouse models of Parkinson's disease associated with mitochondrial dysfunctionGenetically engineered mouse models of Parkinson's diseaseMitochondrial dynamics and mitophagy in Parkinson's disease: disordered cellular power plant becomes a big deal in a major movement disorderMitochondrial dysfunction and oxidative stress in Parkinson's diseaseSex differences in Parkinson's diseaseNear-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 modelTissue- and cell-specific mitochondrial defect in Parkin-deficient miceThe yeast complex I equivalent NADH dehydrogenase rescues pink1 mutantsParkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.Parkinson's disease: animal models and dopaminergic cell vulnerabilityMitochondrial dysfunction associated with glucocerebrosidase deficiencyMitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expressionGene-environment interactions: key to unraveling the mystery of Parkinson's diseaseBeyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health
P2860
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P2860
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
description
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2008
@ast
im August 2008 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2008/08/12)
@sk
vědecký článek publikovaný v roce 2008
@cs
wetenschappelijk artikel (gepubliceerd op 2008/08/12)
@nl
наукова стаття, опублікована в серпні 2008
@uk
name
Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
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Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
@en
Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
@nl
type
label
Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
@ast
Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
@en
Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
@nl
prefLabel
Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
@ast
Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
@en
Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
@nl
P2860
P50
P3181
P356
P1476
Loss of PINK1 causes mitochond ...... ensitivity to oxidative stress
@en
P2860
P304
11364–11369
P356
10.1073/PNAS.0802076105
P4011
8a0e30d37ee8099b980ad7ccfef8fdec78bbf45a
P407
P577
2008-08-12T00:00:00Z