Bub1 regulates chromosome segregation in a kinetochore-independent manner
about
Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interactionBuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignmentC2orf62 and TTC17 are involved in actin organization and ciliogenesis in zebrafish and humanAurora B hyperactivation by Bub1 overexpression promotes chromosome missegregationKNL1: bringing order to the kinetochoreA Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during MitosisPhosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora BStructure of human Mad1 C-terminal domain reveals its involvement in kinetochore targetingBub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signalingMad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint.Bod1 regulates protein phosphatase 2A at mitotic kinetochoresAnalysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinomePhosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshinKinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpointBub1 and Bub3 promote the conversion from monopolar to bipolar chromosome attachment independently of shugoshinMolecular control of kinetochore-microtubule dynamics and chromosome oscillationsDeformations within moving kinetochores reveal different sites of active and passive force generation.The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrestDistinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylationRED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint.Genome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints.E2F1 and KIAA0191 expression predicts breast cancer patient survivalFinding the middle ground: how kinetochores power chromosome congression.Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase.Nucleobindin 2 in human breast carcinoma as a potent prognostic factor.Roles of MAPK and spindle assembly checkpoint in spontaneous activation and MIII arrest of rat oocytes.Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivationSensors at centrosomes reveal determinants of local separase activity.Mutual regulation between the spindle checkpoint and APC/C.Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegansInvolvement of enhancer of zeste homolog 2 in cisplatin-resistance in ovarian cancer cells by interacting with several genes.Characterization of spindle checkpoint kinase Mps1 reveals domain with functional and structural similarities to tetratricopeptide repeat motifs of Bub1 and BubR1 checkpoint kinases.Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomesRole of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1.Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression.Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524.Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.
P2860
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P2860
Bub1 regulates chromosome segregation in a kinetochore-independent manner
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@ast
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@en
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@en-gb
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@nl
type
label
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@ast
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@en
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@en-gb
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@nl
prefLabel
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@ast
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@en
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@en-gb
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@nl
P2860
P921
P3181
P356
P1476
Bub1 regulates chromosome segregation in a kinetochore-independent manner
@en
P2093
Christiane Klebig
Dirk Korinth
P2860
P304
P3181
P356
10.1083/JCB.200902128
P407
P577
2009-06-01T00:00:00Z