A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B
about
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitorThe Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint SignalingCell division: control of the chromosomal passenger complex in time and spaceLoss of the Greatwall Kinase Weakens the Spindle Assembly CheckpointKinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochoresMad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint.The unconventional kinetoplastid kinetochore: from discovery toward functional understandingKinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpointThe human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochoresA Centromere-Signaling Network Underlies the Coordination among Mitotic EventsConnecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.Phosphorylation at threonine 288 by cell cycle checkpoint kinase 2 (CHK2) controls human monopolar spindle 1 (Mps1) kinetochore localization.Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress.The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signalling.A putative N-terminal nuclear export sequence is sufficient for Mps1 nuclear exclusion during interphaseA motif from Lys216 to Lys222 in human BUB3 protein is a nuclear localization signal and critical for BUB3 function in mitotic checkpoint.Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells.The Spindle Assembly Checkpoint Safeguards Genomic Integrity of Skeletal Muscle Satellite Cells.Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachmentGenetic and pharmacological inhibition of TTK impairs pancreatic cancer cell line growth by inducing lethal chromosomal instability.Modular elements of the TPR domain in the Mps1 N terminus differentially target Mps1 to the centrosome and kinetochore.Phosphorylation of microtubule-binding protein Hec1 by mitotic kinase Aurora B specifies spindle checkpoint kinase Mps1 signaling at the kinetochore.Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation.Signalling dynamics in the spindle checkpoint response.Inhibition of the spindle assembly checkpoint kinase Mps-1 as a novel therapeutic strategy in malignant mesothelioma.Dual recognition of chromatin and microtubules by INCENP is important for mitotic progression.Mps1 is SUMO-modified during the cell cycle.Regulation of mitotic progression by the spindle assembly checkpointARHGEF17 sets the timer for retention of Mps1 at kinetochores.Divergent polo box domains underpin the unique kinetoplastid kinetochoreThe hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast.CELL DIVISION CYCLE. Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C.Purification and characterisation of the fission yeast Ndc80 complexPlk1 bound to Bub1 contributes to spindle assembly checkpoint activity during mitosis.A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint.Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochoresAll together now: Polo joins the kinase network controlling the spindle assembly checkpoint in Drosophila.Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing.
P2860
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P2860
A TPR domain–containing N-terminal module of MPS1 is required for its kinetochore localization by Aurora B
description
2013 nî lūn-bûn
@nan
2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
A TPR domain–containing N-term ...... chore localization by Aurora B
@ast
A TPR domain–containing N-term ...... chore localization by Aurora B
@en
A TPR domain–containing N-term ...... chore localization by Aurora B
@nl
type
label
A TPR domain–containing N-term ...... chore localization by Aurora B
@ast
A TPR domain–containing N-term ...... chore localization by Aurora B
@en
A TPR domain–containing N-term ...... chore localization by Aurora B
@nl
prefLabel
A TPR domain–containing N-term ...... chore localization by Aurora B
@ast
A TPR domain–containing N-term ...... chore localization by Aurora B
@en
A TPR domain–containing N-term ...... chore localization by Aurora B
@nl
P2093
P2860
P50
P3181
P356
P1476
A TPR domain–containing N-term ...... chore localization by Aurora B
@en
P2093
Geert J P L Kops
Maria H J van Osch
Mathijs Vleugel
Valeria De Marco
Wilco Nijenhuis
P2860
P304
P3181
P356
10.1083/JCB.201210033
P407
P577
2013-04-15T00:00:00Z