Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking
about
Huntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterationsHIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domainsScyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde trafficRNAi-mediated Hip1R silencing results in stable association between the endocytic machinery and the actin assembly machinery.Crystal Structure at 2.8 Å of Huntingtin-Interacting Protein 1 (HIP1) Coiled-Coil Domain Reveals a Charged Surface Suitable for HIP1 Protein Interactor (HIPPI)Clathrin is important for normal actin dynamics and progression of Sla2p-containing patches during endocytosis in yeastActin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chainStructural definition of the F-actin-binding THATCH domain from HIP1RHuntington's disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcriptionHuntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chainRegulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligaseCPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptorsMutations in AKAP5 disrupt dendritic signaling complexes and lead to electrophysiological and behavioral phenotypes in mice.Clathrin assembly proteins AP180 and CALM in the embryonic rat brain.Recurrent distal 7q11.23 deletion including HIP1 and YWHAG identified in patients with intellectual disabilities, epilepsy, and neurobehavioral problems.Therapeutic approaches to preventing cell death in Huntington diseaseUse of a cryptic splice site for the expression of huntingtin interacting protein 1 in select normal and neoplastic tissues.Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selectionMolecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2.Oncogenic breakdowns in endocytic adaptor proteins.Multiple pathways contribute to the pathogenesis of Huntington disease.An integrative, translational approach to understanding rare and orphan genetically based diseasesHuntingtin-interacting protein 1 phosphorylation by receptor tyrosine kinases.Regulation of glutamate receptor internalization by the spine cytoskeleton is mediated by its PKA-dependent association with CPG2.Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1.Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegenerationAn atypical deletion of the Williams-Beuren syndrome interval implicates genes associated with defective visuospatial processing and autism.Genetic association study of adaptor protein complex 4 with cerebral palsy in a Han Chinese population.Toxicity and endocytosis of spinocerebellar ataxia type 6 polyglutamine domains: role of myosin IIb.Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load.Memory Synapses Are Defined by Distinct Molecular Complexes: A Proposal.Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo
P2860
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P2860
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking
description
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
scientific journal article
@en
vedecký článok (publikovaný 2003/07/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/07/01)
@nl
наукова стаття, опублікована в липні 2003
@uk
مقالة علمية (نشرت في يوليو 2003)
@ar
name
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@ast
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@en
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@nl
type
label
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@ast
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@en
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@nl
prefLabel
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@ast
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@en
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@nl
P2093
P2860
P50
P921
P356
P1433
P1476
Disruption of the endocytic pr ...... ased AMPA receptor trafficking
@en
P2093
Christine Alvarez
Enrique Torre
John C. Roder
Lynn A. Raymond
Martina Metzler
Peter S. McPherson
Rebecca S. Devon
Rosemary Oh
P2860
P304
P356
10.1093/EMBOJ/CDG334
P407
P50
P577
2003-07-01T00:00:00Z