Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing
about
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substratesPOT1 association with TRF2 regulates telomere lengthTelomere dysfunction and cell survival: roles for distinct TIN2-containing complexesHuman protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitroPOT1 and TRF2 cooperate to maintain telomeric integrityPOT1 loss-of-function variants predispose to familial melanomaRescue of an hTERT mutant defective in telomere elongation by fusion with hPot1Finding the end: recruitment of telomerase to telomeresStructure and function of the telomeric CST complexHow telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNACdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere MaintenanceStructure of the Human Telomeric Stn1-Ten1 Capping ComplexA Motif in the Vertebrate Telomerase N-Terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and ProcessivityDNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sitesSwitching human telomerase on and off with hPOT1 protein in vitroPOT1 mutations cause telomere dysfunction in chronic lymphocytic leukemiaStructure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protectionPOT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombinationEvolution of Arabidopsis protection of telomeres 1 alters nucleic acid recognition and telomerase regulationMultiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1.Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stabilityPOT1 protects telomeres from a transient DNA damage response and determines how human chromosomes endThe Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protectionVertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protectionMapping of interaction domains of putative telomere-binding proteins AtTRB1 and AtPOT1b from Arabidopsis thaliana.Distinct functions of POT1 at telomeres.Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenitaPOT1-independent single-strand telomeric DNA binding activities in Brassicaceae.Insights into the dynamics of specific telomeric single-stranded DNA recognition by Pot1pNPOT1 proteins in green algae and land plants: DNA-binding properties and evidence of co-evolution with telomeric DNAStructural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancerPot1 and telomere maintenance.Protection of Telomeres 1 is required for telomere integrity in the moss Physcomitrella patens.PARP1 Is a TRF2-associated poly(ADP-ribose)polymerase and protects eroded telomeres.Telomere stability and development of ctc1 mutants are rescued by inhibition of EJ recombination pathways in a telomerase-dependent manner.Coordinated interactions of multiple POT1-TPP1 proteins with telomere DNA.Telomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase.Replication proteins influence the maintenance of telomere length and telomerase protein stabilityDAZAP1 regulates the splicing of Crem, Crisp2 and Pot1a transcripts.
P2860
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P2860
Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Human Pot1 (protection of telo ...... ture, and alternative splicing
@ast
Human Pot1 (protection of telo ...... ture, and alternative splicing
@en
Human Pot1 (protection of telo ...... ture, and alternative splicing
@nl
type
label
Human Pot1 (protection of telo ...... ture, and alternative splicing
@ast
Human Pot1 (protection of telo ...... ture, and alternative splicing
@en
Human Pot1 (protection of telo ...... ture, and alternative splicing
@nl
prefLabel
Human Pot1 (protection of telo ...... ture, and alternative splicing
@ast
Human Pot1 (protection of telo ...... ture, and alternative splicing
@en
Human Pot1 (protection of telo ...... ture, and alternative splicing
@nl
P2860
P50
P3181
P1476
Human Pot1 (protection of telo ...... ture, and alternative splicing
@en
P2860
P304
P3181
P356
10.1128/MCB.22.22.8079-8087.2002
P407
P577
2002-11-01T00:00:00Z