about
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assemblyGenome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsPOT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substratesConserved telomere maintenance component 1 interacts with STN1 and maintains chromosome ends in higher eukaryotesTelomere protection by mammalian Pot1 requires interaction with Tpp1POT1 association with TRF2 regulates telomere lengthCharacterization of the DNA binding specificity of Shelterin complexesTelomere dysfunction and cell survival: roles for distinct TIN2-containing complexesTelomere protection by TPP1 is mediated by POT1a and POT1bInhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13pPOT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombinationEndogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.Telomere protection by TPP1/POT1 requires tethering to TIN2Distinct requirements for Pot1 in limiting telomere length and maintaining chromosome stabilityPOT1 protects telomeres from a transient DNA damage response and determines how human chromosomes endThe Arabidopsis Pot1 and Pot2 proteins function in telomere length homeostasis and chromosome end protectionAlterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha.Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protectionTelomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumor cells.Arabidopsis POT1 associates with the telomerase RNP and is required for telomere maintenance.Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation.Distinct functions of POT1 at telomeres.Suppression of hPOT1 in diploid human cells results in an hTERT-dependent alteration of telomere length dynamics.STN1 protects chromosome ends in Arabidopsis thaliana.Telomere biology in healthy aging and disease.Pot1 and telomere maintenance.The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines.The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences.PRL-3 promotes telomere deprotection and chromosomal instability.Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers.Telomerase enzymatic component hTERT shortens long telomeres in human cells.Schizosaccharomyces pombe protection of telomeres 1 utilizes alternate binding modes to accommodate different telomeric sequencesDNA damage to a single chromosome end delays anaphase onsetGene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways.Binding linkage in a telomere DNA-protein complex at the ends of Oxytricha nova chromosomes.Telomere length and regulatory proteins in human skeletal muscle with and without ongoing regenerative cycles.A small molecule inhibitor of Pot1 binding to telomeric DNA.
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
POT1 and TRF2 cooperate to maintain telomeric integrity
@ast
POT1 and TRF2 cooperate to maintain telomeric integrity
@en
POT1 and TRF2 cooperate to maintain telomeric integrity
@en-gb
POT1 and TRF2 cooperate to maintain telomeric integrity
@nl
type
label
POT1 and TRF2 cooperate to maintain telomeric integrity
@ast
POT1 and TRF2 cooperate to maintain telomeric integrity
@en
POT1 and TRF2 cooperate to maintain telomeric integrity
@en-gb
POT1 and TRF2 cooperate to maintain telomeric integrity
@nl
prefLabel
POT1 and TRF2 cooperate to maintain telomeric integrity
@ast
POT1 and TRF2 cooperate to maintain telomeric integrity
@en
POT1 and TRF2 cooperate to maintain telomeric integrity
@en-gb
POT1 and TRF2 cooperate to maintain telomeric integrity
@nl
P2093
P2860
P921
P3181
P1476
POT1 and TRF2 cooperate to maintain telomeric integrity
@en
P2093
Curtis C Harris
Yun-Ling Zheng
P2860
P304
P3181
P356
10.1128/MCB.25.3.1070-1080.2005
P407
P577
2005-02-01T00:00:00Z