MafA is a key regulator of glucose-stimulated insulin secretion. - Test2 - elhamkhani - TriplyDB

MafA is a key regulator of glucose-stimulated insulin secretion.

MafA is a key regulator of glucose-stimulated insulin secretion.

http://www.wikidata.org/entity/Q33836891

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Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression MafB is required for islet beta cell maturation FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus Generation of β cells from human pluripotent stem cells: are we there yet?Derivation of insulin-producing beta-cells from human pluripotent stem cells Transcription factor regulation of pancreatic organogenesis, differentiation and maturation Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients Reexpression of oncoprotein MafB in proliferative β-cells and Men1 insulinomas in mouse Nkx2.2 regulates beta-cell function in the mature islet Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development The MafA transcription factor becomes essential to islet β-cells soon after birth.Protein therapy using MafA fused to a polyarginine transduction domain attenuates glucose levels of streptozotocin‑induced diabetic mice.Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis.Phosphorylation within the MafA N terminus regulates C-terminal dimerization and DNA binding.Predicting pancreas cell fate decisions and reprogramming with a hierarchical multi-attractor model.Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes.TAT-mediated transduction of MafA protein in utero results in enhanced pancreatic insulin expression and changes in islet morphology MafA is required for postnatal proliferation of pancreatic β-cells.Xenopus pancreas development Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.Direct lineage conversions: unnatural but useful?The Effect of Tribbles-Related Protein 3 on ER Stress-Suppressed Insulin Gene Expression in INS-1 Cells.A blueprint for engineering cell fate: current technologies to reprogram cell identity.Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA Islet-1 Is essential for pancreatic β-cell function.Acinar-to-ductal metaplasia induced by adenovirus-mediated pancreatic expression of Isl1.Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation The transcription factor Myt3 acts as a pro-survival factor in β-cells Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development MAFA controls genes implicated in insulin biosynthesis and secretion PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells.Colony-forming progenitor cells in the postnatal mouse liver and pancreas give rise to morphologically distinct insulin-expressing colonies in 3D cultures Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3.Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.Transcriptional factors, Mafs and their biological roles

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MafA is a key regulator of glucose-stimulated insulin secretion.

http://www.wikidata.org/entity/Q33836891

description

2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

MafA is a key regulator of glucose-stimulated insulin secretion.

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MafA is a key regulator of glucose-stimulated insulin secretion.

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MafA is a key regulator of glucose-stimulated insulin secretion.

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MafA is a key regulator of glucose-stimulated insulin secretion.

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MCB.25.12.4969-4976.2005

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Molecular and Cellular Biology

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MafA is a key regulator of glucose-stimulated insulin secretion.

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Ayako Harada

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Chuan Zhang

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Hisashi Oishi

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Homare Shimohata

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James Douglas Engel

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Kazuteru Hasegawa

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Masayuki Yamamoto

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Michito Hamada

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Miwako Kajihara

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Naoki Morito

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P2860

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

A conserved retina-specific gene encodes a basic motif/leucine zipper domain

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.

v-maf, a viral oncogene that encodes a "leucine zipper" motif

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

Method for the isolation of intact islets of Langerhans from the rat pancreas

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

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4969-4976

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7817586

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