Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia - Test2 - elhamkhani - TriplyDB

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

http://www.wikidata.org/entity/Q24634306

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The mouse genetics toolkit: revealing function and mechanism CtIP is required to initiate replication-dependent interstrand crosslink repair FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes Molecular pathogenesis and clinical management of Fanconi anemia Fanconi anemia complementation group A (FANCA) protein has intrinsic affinity for nucleic acids with preference for single-stranded forms Nucleases in homologous recombination as targets for cancer therapy Modeling the study of DNA damage responses in mice The Fanconi anemia pathway and DNA interstrand cross-link repair Learning from a paradox: recent insights into Fanconi anaemia through studying mouse models Mechanisms and regulation of mitotic recombination in Saccharomyces cerevisiae Mechanism and regulation of incisions during DNA interstrand cross-link repair Pathways for repairing and tolerating the spectrum of oxidative DNA lesions Diseases associated with defective responses to DNA damage DNA repair endonuclease ERCC1-XPF as a novel therapeutic target to overcome chemoresistance in cancer therapy Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast.Role of Saw1 in Rad1/Rad10 complex assembly at recombination intermediates in budding yeast XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4 Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease Fancf-deficient mice are prone to develop ovarian tumours Uncoupling of transcription and translation of Fanconi anemia (FANC) complex proteins during spermatogenesis Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia Malfunction of nuclease ERCC1-XPF results in diverse clinical manifestations and causes Cockayne syndrome, xeroderma pigmentosum, and Fanconi anemia Advances in understanding the complex mechanisms of DNA interstrand cross-link repair A never-ending story: the steadily growing family of the FA and FA-like genes Fanconi anemia proteins and their interacting partners: a molecular puzzle Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.CtIP mediates replication fork recovery in a FANCD2-regulated manner.Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways.Exploring the link between MORF4L1 and risk of breast cancer.Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling Fanconi anemia core complex gene promoters harbor conserved transcription regulatory elements.Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families.Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

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Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

http://www.wikidata.org/entity/Q24634306

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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Nature Genetics

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Disruption of mouse Slx4, a re ...... es, phenocopies Fanconi anemia

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David J Adams

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Frederic Langevin

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Ketan J Patel

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Kevin Brindle

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Mark J Arends

http://www.w3.org/2001/XMLSchema#string

Rebecca E McIntyre

http://www.w3.org/2001/XMLSchema#string

P2860

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

BRCTx is a novel, highly conserved RAD18-interacting protein

FANCE: the link between Fanconi anaemia complex assembly and activity

Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.

Mice with a targeted disruption of the Fanconi anemia homolog Fanca

Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice

Xpf and not the Fanconi anaemia proteins or Rev3 accounts for the extreme resistance to cisplatin in Dictyostelium discoideum

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147-52

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scholarly article

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4948308

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10.1038/NG.752

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2

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43

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Louise van der Weyden

Ferdia A Gallagher

Pierre-Henri L Gaillard

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2011-02-01T00:00:00Z

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49760524

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1032349974

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21240276

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3624090

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