XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4 - Test2 - elhamkhani - TriplyDB

XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4

XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4

http://www.wikidata.org/entity/Q28238027

about

DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress Cellular response to DNA interstrand crosslinks: the Fanconi anemia pathway How SUMOylation Fine-Tunes the Fanconi Anemia DNA Repair Pathway Interplay between Fanconi anemia and homologous recombination pathways in genome integrity Effects of Charged Particles on Human Tumor Cells Role of Deubiquitinating Enzymes in DNA Repair Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy Mechanism and regulation of incisions during DNA interstrand cross-link repair Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5' flap DNA: basis of interstrand cross-link repair by FAN1.Maternal aldehyde elimination during pregnancy preserves the fetal genome Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer.FANCD2-associated nuclease 1, but not exonuclease 1 or flap endonuclease 1, is able to unhook DNA interstrand cross-links in vitro Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.Crystal structure of human Fanconi-associated nuclease 1.DNA interstrand cross-link repair requires replication-fork convergence.Defective FANCI binding by a fanconi anemia-related FANCD2 mutant.SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites.Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing.Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA.The ERCC1 and ERCC4 (XPF) genes and gene products Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.Regulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link FANCD2, FANCJ and BRCA2 cooperate to promote replication fork recovery independently of the Fanconi Anemia core complex.RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold.Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.Natural history and management of Fanconi anemia patients with head and neck cancer: A 10-year follow-up.Replication stress and cancer: it takes two to tango.The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2.Nuclear alpha spectrin: Critical roles in DNA interstrand cross-link repair and genomic stability.FANCJ is essential to maintain microsatellite structure genome-wide during replication stress.The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η p97 Promotes a Conserved Mechanism of Helicase Unloading during DNA Cross-Link Repair.Stress and DNA repair biology of the Fanconi anemia pathway Fanconi anaemia: genetics, molecular biology, and cancer – implications for clinical management in children and adults.The Fanconi anemia ID2 complex: dueling saxes at the crossroads.The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81.

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P2860

XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4

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2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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XPF-ERCC1 acts in Unhooking DN ...... ion with FANCD2 and FANCP/SLX4

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XPF-ERCC1 acts in Unhooking DN ...... ion with FANCD2 and FANCP/SLX4

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XPF-ERCC1 acts in Unhooking DN ...... ion with FANCD2 and FANCP/SLX4

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XPF-ERCC1 acts in Unhooking DN ...... ion with FANCD2 and FANCP/SLX4

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XPF-ERCC1 acts in Unhooking DN ...... ion with FANCD2 and FANCP/SLX4

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J.MOLCEL.2014.03.015

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Anna A Szypowska

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Daisy Klein Douwel

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Markus Räschle

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P2860

Regulation of Rev1 by the Fanconi anemia core complex

Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2

Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair

Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C

Mutations of the SLX4 gene in Fanconi anemia

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

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460-471

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scholarly article

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10.1016/J.MOLCEL.2014.03.015

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3

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Johannes C Walter

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261607405

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