Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling - Test2 - elhamkhani - TriplyDB

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

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Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfism Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.Linking kinetochore-microtubule binding to the spindle checkpoint When 2+2=5: the origins and fates of aneuploid and tetraploid cells Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore Force generation by kinesin and myosin cytoskeletal motor proteins Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components.Chromosomes can congress to the metaphase plate before biorientation.Defining the Molecular Basis of BubR1 Kinetochore Interactions and APC/C-CDC20 Inhibition Cell division: righting the check.Mitotic chromosome biorientation in fission yeast is enhanced by dynein and a minus-end-directed, kinesin-like protein The mitotic kinesin CENP-E is a processive transport motor.Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches.Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.TopoIIα prevents telomere fragility and formation of ultra thin DNA bridges during mitosis through TRF1-dependent binding to telomeres Cenp-meta is required for sustained spindle checkpoint Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation.Targeting a kinetochore-associated motor protein to kill cancer cells.Finding the middle ground: how kinetochores power chromosome congression.Prognostic significance and therapeutic implications of centromere protein F expression in human nasopharyngeal carcinoma CENP-E--dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint.How chromosome mis-segregation leads to cancer: lessons from BubR1 mouse models Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E.Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin.Loading of the 3F3/2 antigen onto kinetochores is dependent on the ordered assembly of the spindle checkpoint proteins.Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program.Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells Gene expression profiles in promoted-growth rice seedlings that germinated from the seeds implanted by low-energy N+ beam.How to build a centromere: from centromeric and pericentromeric chromatin to kinetochore assembly.Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization.New insights into the mechanism for chromosome alignment in metaphase Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.UA62784, a novel inhibitor of centromere protein E kinesin-like protein

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Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

http://www.wikidata.org/entity/Q24679267

description

2005 nî lūn-bûn

@nan

2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

@wuu

name

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@ast

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@en

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@nl

type

label

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@ast

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@en

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@nl

prefLabel

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@ast

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@en

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@nl

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Journal of Cell Biology

P1476

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling

@en

P2093

Arshad Desai

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1

Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores

ZW10 links mitotic checkpoint signaling to the structural kinetochore.

Identification of a human mitotic checkpoint gene: hsMAD2

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

Mutations of mitotic checkpoint genes in human cancers

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints

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873-880

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scholarly article

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10.1083/JCB.200505040

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6

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170

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Don W Cleveland

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2005-09-06T00:00:00Z

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7616345

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16144904

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2171436

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