Structure of the A20 OTU domain and mechanistic insights into deubiquitination
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Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7Phosphorylation-dependent activity of the deubiquitinase DUBAActivation of interferon regulatory factor 5 by site specific phosphorylationEvidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesisTrabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chainsMolecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chainsLys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase CezanneRegulation and cellular roles of ubiquitin-specific deubiquitinating enzymesAutophagy-Related Deubiquitinating Enzymes Involved in Health and DiseaseUbiquitin in the immune systemMolecular Basis for the Unique Deubiquitinating Activity of the NF-κB Inhibitor A20Structural Analysis of a Viral Ovarian Tumor Domain Protease from the Crimean-Congo Hemorrhagic Fever Virus in Complex with Covalently Bonded UbiquitinStructural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing proteaseSpecific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulationAn ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chainsRegulation of A20 and other OTU deubiquitinases by reversible oxidationMolecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.Molecular basis for specificity of the Met1-linked polyubiquitin signalThe ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signalsOTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN levelIdentification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen.The complexities of p97 function in health and diseaseInvolvement of KDM1C histone demethylase-OTLD1 otubain-like histone deubiquitinase complexes in plant gene repression.African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunityEvolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family.Upregulated Expression of A20 on Monocytes is Associated With Increased Severity of Acute-on-Chronic Hepatitis B Liver Failure: A Case-Control Study.A20: linking a complex regulator of ubiquitylation to immunity and human diseaseTGF-β induces miR-182 to sustain NF-κB activation in glioma subsets.The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death.Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling.Deubiquitylation and regulation of the immune response.A20: central gatekeeper in inflammation and immunity.Ubiquitin in NF-kappaB signaling.The porcine reproductive and respiratory syndrome virus nsp2 cysteine protease domain possesses both trans- and cis-cleavage activities.Polyubiquitin binding and disassembly by deubiquitinating enzymes.Genetics of rheumatic disease.Distinct phylogenetic relationships and biochemical properties of Arabidopsis ovarian tumor-related deubiquitinases support their functional differentiation.Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains.
P2860
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P2860
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@ast
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@en
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@nl
type
label
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@ast
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@en
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@nl
prefLabel
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@ast
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@en
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@nl
P356
P1433
P1476
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
@en
P2093
David Barford
P356
10.1042/BJ20071399
P407
P577
2008-01-01T00:00:00Z