A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
about
Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signalsEvidence for the involvement of p38 MAPK activation in barnacle larval settlementStructural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificityMolecular basis of MAPK-activated protein kinase 2:p38 assemblyStructure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational AnalysesFluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α KinaseX-ray structure of p38α bound to TAK-715: comparison with three classic inhibitorsTAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1Specificity and mechanism of action of some commonly used protein kinase inhibitorsThe Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.Role of p38 MAP kinase in LPS-induced airway inflammation in the ratRequirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expressionForward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinasesComparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δProtein kinases--the major drug targets of the twenty-first century?A small molecule-kinase interaction map for clinical kinase inhibitorsTumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistanceDevelopment of a p38 Kinase Binding Assay for High Throughput Screening.Supernatant from bifidobacterium differentially modulates transduction signaling pathways for biological functions of human dendritic cells.Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screeningA network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.Structural determinants of PERK inhibitor potency and selectivityIdentification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling.T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascadeFeline leukemia virus long terminal repeat activates collagenase IV gene expression through AP-1A mitogen-activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host.Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathwayConference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway.Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury.Virtual screening using a conformationally flexible target protein: models for ligand binding to p38α MAPK.An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replicationRole of p38 and p44/42 mitogen-activated protein kinases in microglia.Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity.'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophilsExtracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle.
P2860
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P2860
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
description
1997 nî lūn-bûn
@nan
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@ast
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@en
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@nl
type
label
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@ast
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@en
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@nl
prefLabel
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@ast
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@en
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@nl
P2093
P2860
P3181
P356
P1476
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
@en
P2093
C A Pargellis
P2860
P304
P3181
P356
10.1038/NSB0497-311
P50
P577
1997-04-01T00:00:00Z