TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II - Test2 - elhamkhani - TriplyDB

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

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Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1 Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK ATM, the Mre11/Rad50/Nbs1 complex, and topoisomerase I are concentrated in the nucleus of Purkinje neurons in the juvenile human brain Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation Emerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical example TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage Processing of damaged DNA ends for double-strand break repair in mammalian cells BRCA1: a novel prognostic factor in resected non-small-cell lung cancer Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay Mitotic chromosomes are constrained by topoisomerase II-sensitive DNA entanglements.The DNA binding and 3'-end preferential activity of human tyrosyl-DNA phosphodiesterase.SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivity Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.Neurological disorders associated with DNA strand-break processing enzymes.Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors Structure-function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.Synthesis and biological evaluation of the first dual tyrosyl-DNA phosphodiesterase I (Tdp1)-topoisomerase I (Top1) inhibitors.TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.Repair of topoisomerase I-mediated DNA damage.Tyrosyl-DNA phosphodiesterase as a target for anticancer therapy WRN protects against topo I but not topo II inhibitors by preventing DNA break formation Bacterial topoisomerase I as a target for discovery of antibacterial compounds.Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.4-Pregnen-21-ol-3,20-dione-21-(4-bromobenzenesulfonate) (NSC 88915) and related novel steroid derivatives as tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors.Topoisomerase I as a biomarker: detection of activity at the single molecule level.Tyrosyl-DNA phosphodiesterase I resolves both naturally and chemically induced DNA adducts and its potential as a therapeutic target.Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan Identification of a putative Tdp1 inhibitor (CD00509) by in vitro and cell-based assays.Production and function of the cytoplasmic deproteinized relaxed circular DNA of hepadnaviruses.TDP1 promotes assembly of non-homologous end joining protein complexes on DNA.TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan.Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.Dysregulated human Tyrosyl-DNA phosphodiesterase I acts as cellular toxin.

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TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II

http://www.wikidata.org/entity/Q28288660

description

2004 nî lūn-bûn

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2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

TDP1 overexpression in human c ...... ted by topoisomerases I and II

@ast

TDP1 overexpression in human c ...... ted by topoisomerases I and II

@en

TDP1 overexpression in human c ...... ted by topoisomerases I and II

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type

label

TDP1 overexpression in human c ...... ted by topoisomerases I and II

@ast

TDP1 overexpression in human c ...... ted by topoisomerases I and II

@en

TDP1 overexpression in human c ...... ted by topoisomerases I and II

@nl

prefLabel

TDP1 overexpression in human c ...... ted by topoisomerases I and II

@ast

TDP1 overexpression in human c ...... ted by topoisomerases I and II

@en

TDP1 overexpression in human c ...... ted by topoisomerases I and II

@nl

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Journal of Biological Chemistry

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TDP1 overexpression in human c ...... ted by topoisomerases I and II

@en

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Christian Mielke

http://www.w3.org/2001/XMLSchema#string

Hans U Barthelmes

http://www.w3.org/2001/XMLSchema#string

Heidrun Interthal

http://www.w3.org/2001/XMLSchema#string

Jeffrey J Pouliot

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Michael Habermeyer

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Morten O Christensen

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P2860

DNA T OPOISOMERASES : Structure, Function, and Mechanism

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

Cell cycle-coupled relocation of types I and II topoisomerases and modulation of catalytic enzyme activities

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

Crystal structure of a transition state mimic for Tdp1 assembled from vanadate, DNA, and a topoisomerase I-derived peptide

Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage.

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes.

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1.

The role of TDP1 from budding yeast in the repair of DNA damage.

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55618-25

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scholarly article

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10.1074/JBC.M405042200

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53

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279

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2004-12-31T00:00:00Z

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15494395

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