Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia - Test2 - elhamkhani - TriplyDB

Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

http://www.wikidata.org/entity/Q28237402

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Role of Nrf1 in antioxidant response element-mediated gene expression and beyond Redox mechanisms in hepatic chronic wound healing and fibrogenesis Hepatocellular carcinoma mouse models: Hepatitis B virus-associated hepatocarcinogenesis and haploinsufficient tumor suppressor genes mTORC1 signaling activates NRF1 to increase cellular proteasome levels Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion Induction of Herpud1 expression by ER stress is regulated by Nrf1 Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1 Nuclear factor-erythroid 2-related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expression Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner Regulation of Nrf2-an update The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance Transcription factor Nrf1 is negatively regulated by its O-GlcNAcylation status Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis.Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice.Identification of two critically deleted regions within chromosome segment 7q35-q36 in EVI1 deregulated myeloid leukemia cell lines Altered inflammatory responses to Citrobacter rodentium infection, but not bacterial lipopolysaccharide, in mice lacking the Cyp4a10 or Cyp4a14 genes.Fast food diet with CCl4 micro-dose induced hepatic-fibrosis--a novel animal model.Nonalcoholic steatohepatitis-associated hepatocellular carcinoma: our case series and literature review Basic leucine zipper protein Cnc-C is a substrate and transcriptional regulator of the Drosophila 26S proteasome.Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells.Oxidative stress and hepatic Nox proteins in chronic hepatitis C and hepatocellular carcinoma.Transgenic expression of entire hepatitis B virus in mice induces hepatocarcinogenesis independent of chronic liver injury Regulation of notch1 signaling by nrf2: implications for tissue regeneration

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P2860

Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia

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Candy Lee

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Jefferson Y Chan

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Laura Leung

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Linyun Chen

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Zhenrong Xu

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P2860

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.

Regulation of JNK signaling by GSTp

Inflammation and cancer

The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts

Nrf1 is critical for redox balance and survival of liver cells during development

Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1

Mechanisms of hepatotoxicity

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease

Nrf2 is essential for protection against acute pulmonary injury in mice

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15738389

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Steatohepatitis

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