Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms
about
The role of the ubiquitin proteasome system in cerebellar development and medulloblastomaBioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates.The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expressionProteasome-mediated processing of Nrf1 is essential for coordinate induction of all proteasome subunits and p97Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymesGlycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1The casein kinase 2-nrf1 axis controls the clearance of ubiquitinated proteins by regulating proteasome gene expressionHrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosisRegulation of proteasome activity in health and diseaseTranscription factor Nrf1 is negatively regulated by its O-GlcNAcylation statusIcariin induces synoviolin expression through NFE2L1 to protect neurons from ER stress-induced apoptosisCharacterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genesUbiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy.Direct interaction between the WD40 repeat protein WDR-23 and SKN-1/Nrf inhibits binding to target DNA.Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation.Transcription factor Nrf1 is topologically repartitioned across membranes to enable target gene transactivation through its acidic glucose-responsive domainsDiscovery of an NRF1-specific inducer from a large-scale chemical library using a direct NRF1-protein monitoring system.The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expressionNrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.Ubiquitin receptors and protein quality controlThe membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity.The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exitAn overview of transcriptional regulation in response to toxicological insult.The evolving role of ubiquitin modification in endoplasmic reticulum-associated degradation.Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction.The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.Multiple regulatory mechanisms of the biological function of NRF3 (NFE2L3) control cancer cell proliferation.Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2).A partnership with the proteasome; the destructive nature of GSK3.Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1Nach Is a Novel Subgroup at an Early Evolutionary Stage of the CNC-bZIP Subfamily Transcription Factors from the Marine Bacteria to Humans
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P2860
Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms
description
2011 nî lūn-bûn
@nan
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Dual regulation of the transcr ...... pendent degradation mechanisms
@ast
Dual regulation of the transcr ...... pendent degradation mechanisms
@en
Dual regulation of the transcr ...... pendent degradation mechanisms
@nl
type
label
Dual regulation of the transcr ...... pendent degradation mechanisms
@ast
Dual regulation of the transcr ...... pendent degradation mechanisms
@en
Dual regulation of the transcr ...... pendent degradation mechanisms
@nl
prefLabel
Dual regulation of the transcr ...... pendent degradation mechanisms
@ast
Dual regulation of the transcr ...... pendent degradation mechanisms
@en
Dual regulation of the transcr ...... pendent degradation mechanisms
@nl
P2093
P2860
P921
P3181
P356
P1476
Dual regulation of the transcr ...... pendent degradation mechanisms
@en
P2093
Masayuki Yamamoto
Shun-ichiro Iemura
Tomoko Morita
Yoshiki Tsuchiya
P2860
P304
P3181
P356
10.1128/MCB.05663-11
P407
P577
2011-11-01T00:00:00Z