Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function - Test2 - elhamkhani - TriplyDB

Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function

Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function

http://www.wikidata.org/entity/Q28239381

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Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity Role of Nrf1 in antioxidant response element-mediated gene expression and beyond Regulation of glutathione synthesis Glutathione synthesis mTORC1 signaling activates NRF1 to increase cellular proteasome levels Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression The p65 isoform of Nrf1 is a dominant negative inhibitor of ARE-mediated transcription Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum Induction of Herpud1 expression by ER stress is regulated by Nrf1 The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1 Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2 Bioanalysis of eukaryotic organelles Stress-activated cap'n'collar transcription factors in aging and human disease Dietary chemoprevention strategies for induction of phase II xenobiotic-metabolizing enzymes in lung carcinogenesis: A review Regulation of proteasome activity in health and disease Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes MCRS2 represses the transactivation activities of Nrf1.Regulation of clock-controlled genes in mammals.Cyanide-induced apoptosis of dopaminergic cells is promoted by BNIP3 and Bax modulation of endoplasmic reticulum-mitochondrial Ca2+ levels.Mechanisms and functions of Nrf2 signaling in Drosophila.The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells.PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation.NFE2L3 (NRF3): the Cinderella of the Cap'n'Collar transcription factors.NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis.Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis

P2860

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P2860

Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function

http://www.wikidata.org/entity/Q28239381

description

2006 nî lūn-bûn

@nan

2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի հուլիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

Nrf1 is targeted to the endopl ...... ation and transacting function

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Nrf1 is targeted to the endopl ...... ation and transacting function

@en

Nrf1 is targeted to the endopl ...... ation and transacting function

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type

label

Nrf1 is targeted to the endopl ...... ation and transacting function

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Nrf1 is targeted to the endopl ...... ation and transacting function

@en

Nrf1 is targeted to the endopl ...... ation and transacting function

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prefLabel

Nrf1 is targeted to the endopl ...... ation and transacting function

@ast

Nrf1 is targeted to the endopl ...... ation and transacting function

@en

Nrf1 is targeted to the endopl ...... ation and transacting function

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P1433

Journal of Biological Chemistry

P1476

Nrf1 is targeted to the endopl ...... ation and transacting function

@en

P2093

Jefferson Y Chan

http://www.w3.org/2001/XMLSchema#string

Weiping Wang

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1

Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice.

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast

CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P.

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Isolation of cDNA encoding the human NF-E2 protein

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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19676-87

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scholarly article

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2388551

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P356

10.1074/JBC.M602802200

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28

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P478

281

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2006-07-14T00:00:00Z

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16687406

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P921

transmembrane protein

endoplasmic reticulum