MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
about
Multiple roles of ATM in monitoring and maintaining DNA integrityMammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaksClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationA Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage ResponseDNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosisYeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodelingA viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responsesDistinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesisHistone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaksCell-cycle checkpoints and cancerNFBD1/MDC1 associates with p53 and regulates its function at the crossroad between cell survival and death in response to DNA damageSUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damageGiraffe genome sequence reveals clues to its unique morphology and physiology.SMYD3 Promotes Homologous Recombination via Regulation of H3K4-mediated Gene Expression.SUMOylation and de-SUMOylation in response to DNA damage.Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometryDNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation.MDC1 interacts with Rad51 and facilitates homologous recombination.The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks.Give me a break, but not in mitosis: the mitotic DNA damage response marks DNA double-strand breaks with early signaling eventsOligomerization of MDC1 protein is important for proper DNA damage responseSumoylation of MDC1 is important for proper DNA damage response.Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1DNA damage checkpoints in mammals.Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining.Family cancer syndromes: inherited deficiencies in systems for the maintenance of genomic integrity.OGT restrains the expansion of DNA damage signalingImpaired DNA damage response--an Achilles' heel sensitizing cancer to chemotherapy and radiotherapy.14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response.Various modes of cell death induced by DNA damage.DNA in motion during double-strand break repair.DNA damage response in plants: conserved and variable response compared to animals.MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition.Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation.STAT3 modulates the DNA damage response pathway.The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage.Cooperative control of Crb2 by ATM family and Cdc2 kinases is essential for the DNA damage checkpoint in fission yeast.Genome Instability and γH2AX.The γH2AX assay for genotoxic and nongenotoxic agents: comparison of H2AX phosphorylation with cell death response.
P2860
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P2860
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
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2004 nî lūn-bûn
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2004 թուականին հրատարակուած գիտական յօդուած
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2004 թվականին հրատարակված գիտական հոդված
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2004年の論文
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MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
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MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
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MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
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MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
@ast
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
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MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
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MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
@ast
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
@en
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
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P3181
P1433
P1476
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
@en
P2093
Manuel Stucki
P3181
P356
10.1016/J.DNAREP.2004.03.007
P407
P577
2004-01-01T00:00:00Z