about
Large-scale structural analysis of the classical human protein tyrosine phosphatomeStructural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4Structure of PICK1 and other PDZ domains obtained with the help of self-binding C-terminal extensions8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase InhibitorsCrystal structures of histone demethylase JMJD2A reveal basis for substrate specificityStructures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate RecognitionCrystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing MutationsRVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomainType II Inhibitors Targeting CDK2Assessing histone demethylase inhibitors in cells: lessons learned.Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changesA small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.Selective targeting of Bromodomains of the Bromodomain-PHD Fingers family impairs osteoclast differentiation.Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.Frapid: achieving full automation of FRAP for chemical probe validationDesign of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.Expression and purification of recombinant human inward rectifier K+ (KCNJ) channels in Saccharomyces cerevisiae.Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.High throughput production of recombinant human proteins for crystallography.In Vivo Biotinylation of Antigens in E. coli.
P50
Q24321557-5FD23CA3-7A9C-4392-9A1C-403E86C3EB6AQ24323322-003DAB69-05A7-4CB1-95F0-3240CA5A05C5Q27644225-C62421BE-3F74-40D7-B04A-FC019C8059DBQ27644640-A1282ADF-9C71-4835-964B-A01DC57DBD84Q27646391-50BB9C46-A47D-4413-BA78-1EC7ACD1A2C6Q27678087-FC015268-4D75-44ED-8CE1-D5C232A2BF4CQ27678727-4272126C-5B45-4687-AC83-618E4CE8AA06Q27680635-FBDB6B94-521C-43B8-85EB-A91DF4D5711CQ27701541-7C12DD36-E821-4187-B9D6-0F5ED56AFAB6Q30361704-60945401-8F4F-4DB3-B34B-0FC11CB6E1F7Q30668581-24100D6F-5227-482D-9EF3-AE5A1DE2F66FQ31814838-575C94DE-A655-446A-8C2B-9040369AEE23Q34564351-0054EE6A-05E9-4E87-AFC8-4F3FA6DBFD03Q37525441-825670C7-3164-464A-91A9-80E86F545DB3Q38604141-B36A8D59-D19F-43F2-99D8-1697F72073B6Q38668625-0DB52848-B088-4B7F-9C3D-1CF25498EAA9Q38681544-485A4AB2-7EA6-4CC5-A697-D178DD79F29BQ38722339-64F7D445-F66A-4DDE-8605-89DDC3898EFCQ39985743-1332DF62-508C-4DD6-B321-C3FBF3430ED5Q41781559-858330D1-6893-4C55-AF6F-B0050A15E45DQ42291026-853B7169-01F1-490E-A4F2-E508CA720FD2Q47649125-DA7EC990-FF20-4F1E-8808-94365088B698Q51021185-F8716A4B-6CAA-4472-8E32-ADDA99CD6D0B
P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Pavel Savitsky
@ast
Pavel Savitsky
@en
Pavel Savitsky
@es
Pavel Savitsky
@nl
Pavel Savitsky
@sl
type
label
Pavel Savitsky
@ast
Pavel Savitsky
@en
Pavel Savitsky
@es
Pavel Savitsky
@nl
Pavel Savitsky
@sl
prefLabel
Pavel Savitsky
@ast
Pavel Savitsky
@en
Pavel Savitsky
@es
Pavel Savitsky
@nl
Pavel Savitsky
@sl