A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. - Test2 - elhamkhani - TriplyDB

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

http://www.wikidata.org/entity/Q34564351

about

Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism.The role of post-translational modifications in fine-tuning BLM helicase function during DNA repair Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells Targeting the homologous recombination pathway by small molecule modulators Unravelling the genomic targets of small molecules using high-throughput sequencing.Discovering new medicines targeting helicases: challenges and recent progress.Non-stoichiometric inhibition in integrated lead finding - a literature review.DNA helicases involved in DNA repair and their roles in cancer Human RecQ helicases in DNA repair, recombination, and replication.RECQ helicases are deregulated in hematological malignancies in association with a prognostic value The BLM dissolvasome in DNA replication and repair.Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.Common Chemical Inductors of Replication Stress: Focus on Cell-Based Studies.Targeting homologous recombination-mediated DNA repair in cancer.Helicases, G4-DNAs, and drug design.Structural mechanisms of human RecQ helicases WRN and BLM.Therapeutic opportunities within the DNA damage response.A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers.Biochemical and cell biological assays to identify and characterize DNA helicase inhibitors.Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair.ALTernative Telomere Maintenance and Cancer.A new development in DNA repair modulation: discovery of a BLM helicase inhibitor.Characterization of the EBV-Induced Persistent DNA Damage Response.Integrative genomic and transcriptomic analysis of leiomyosarcoma.Breaking the end: Target the replication stress response at the ALT telomeres for cancer therapy.The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells.MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways.New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy DNA Repair Molecular Beacon assay: a platform for real-time functional analysis of cellular DNA repair capacity

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P2860

A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

http://www.wikidata.org/entity/Q34564351

description

2013 nî lūn-bûn

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2013 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2013 թվականի հունվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年论文

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A small molecule inhibitor of ...... some stability in human cells.

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A small molecule inhibitor of ...... some stability in human cells.

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A small molecule inhibitor of ...... some stability in human cells.

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A small molecule inhibitor of ...... some stability in human cells.

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A small molecule inhibitor of ...... some stability in human cells.

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A small molecule inhibitor of ...... some stability in human cells.

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J.CHEMBIOL.2012.10.016

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Chemistry and Biology

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A small molecule inhibitor of ...... some stability in human cells.

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Andrew S Rosenthal

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Csanád Z Bachrati

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Curtis C Harris

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David J Maloney

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Dharmendra Kumar Singh

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Georgina Mosedale

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Giang Huong Nguyen

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Ian D Hickson

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Lena Schultz

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Masaaki Sakurai

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P2860

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity

The Bloom's syndrome gene product is homologous to RecQ helicases

BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome

A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome

Structure of the human RECQ1 helicase reveals a putative strand-separation pin

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase

RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex

The Bloom's syndrome gene product interacts with topoisomerase III

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