Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
about
Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.Mutations in CENPE define a novel kinetochore-centromeric mechanism for microcephalic primordial dwarfismFunctional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interferenceSilencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death.CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore-microtubule attachment.The human spindle assembly checkpoint protein Bub3 is required for the establishment of efficient kinetochore-microtubule attachments.Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome lossGene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delayLethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.A mitotic septin scaffold required for Mammalian chromosome congression and segregationSUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosisWhen 2+2=5: the origins and fates of aneuploid and tetraploid cellsNup358 integrates nuclear envelope breakdown with kinetochore assemblyMicrotubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signalingDNA damage associated with mitosis and cytokinesis failureSUMOylation in control of accurate chromosome segregation during mitosisRole of the Number of Microtubules in Chromosome Segregation during Cell DivisionMouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential.Chromosomes can congress to the metaphase plate before biorientation.TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment.Chromokinesin Kid and kinetochore kinesin CENP-E differentially support chromosome congression without end-on attachment to microtubulesCTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding SitesChromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways.Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerasesFoxM1 is required for execution of the mitotic programme and chromosome stabilityMouse emi1 has an essential function in mitotic progression during early embryogenesisThe E4F protein is required for mitotic progression during embryonic cell cyclesThe Ndc80 complex: integrating the kinetochore's many movements.CLIP-170 facilitates the formation of kinetochore-microtubule attachments.Xorbit/CLASP links dynamic microtubules to chromosomes in the Xenopus meiotic spindle.Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.Chromosome congression in the absence of kinetochore fibres.Molecular control of kinetochore-microtubule dynamics and chromosome oscillationsMitotic kinesin CENP-E promotes microtubule plus-end elongation.Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defectUp-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisonsEvolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cellsChromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpointKinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.
P2860
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P2860
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
description
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
scientific journal article
@en
vedecký článok (publikovaný 2002/09/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/09/01)
@nl
wissenschaftlicher Artikel
@de
наукова стаття, опублікована у вересні 2002
@uk
مقالة علمية (نشرت في سبتمبر 2002)
@ar
name
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@ast
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@en
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@nl
type
label
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@ast
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@en
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@nl
prefLabel
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@ast
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@en
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@nl
P2093
P50
P921
P3181
P1433
P1476
Unstable kinetochore-microtubu ...... y following deletion of CENP-E
@en
P2093
Alain D Silk
Frances R Putkey
J Richard McIntosh
Mary K Morphew
P304
P3181
P356
10.1016/S1534-5807(02)00255-1
P407
P577
2002-09-01T00:00:00Z