Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors. - Test2 - elhamkhani - TriplyDB

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.

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Targeting the Mitotic Catastrophe Signaling Pathway in Cancer Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells.Role of the Number of Microtubules in Chromosome Segregation during Cell Division Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies Development of a novel HAC-based "gain of signal" quantitative assay for measuring chromosome instability (CIN) in cancer cells Resveratrol and aspirin eliminate tetraploid cells for anticancer chemoprevention.Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability.Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues.The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E.The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Microsatellite alteration in multiple primary lung cancer.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.The oncogenic role of the cochaperone Sgt1 Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification MYC Is a Major Determinant of Mitotic Cell Fate.Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.Defects in MAP1S-mediated autophagy cause reduction in mouse lifespans especially when fibronectin is overexpressed Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies.Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells.Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth.High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation.Mps1 kinase regulates tumor cell viability via its novel role in mitochondria Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy.Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments.The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis.Mechanisms of Chromosome Congression during Mitosis.Functionality of the chromosomal passenger complex in cancer.How to be good at being bad: centrosome amplification and mitotic propensity drive intratumoral heterogeneity.Centromere Silencing Mechanisms.The Janus soul of centrosomes: a paradoxical role in disease?Centrosomal clustering contributes to chromosomal instability and cancer.Nuclear import mechanism of neurofibromin for localization on the spindle and function in chromosome congression.Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy.Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation.Emerging links among Chromosome Instability (CIN), cancer, and aging.Frequently mutated genes/pathways and genomic instability as prevention targets in liver cancer.Aneuploidy in Cancer and Aging.

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Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.

http://www.wikidata.org/entity/Q30556712

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Chromosome missegregation rate ...... ll promote or suppress tumors.

@ast

Chromosome missegregation rate ...... ll promote or suppress tumors.

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type

label

Chromosome missegregation rate ...... ll promote or suppress tumors.

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Chromosome missegregation rate ...... ll promote or suppress tumors.

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prefLabel

Chromosome missegregation rate ...... ll promote or suppress tumors.

@ast

Chromosome missegregation rate ...... ll promote or suppress tumors.

@en

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PNAS.1317042110

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Proceedings of the National Academy of Sciences of the United States of America

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Chromosome missegregation rate ...... ill promote or suppress tumors

@en

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Alain D Silk

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Andrew J Holland

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Beth A Weaver

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Lauren M Zasadil

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P2860

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment

Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E

Mouse models for hereditary nonpolyposis colorectal cancer

Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice

Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2

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E4134-41

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scholarly article

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44

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110

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Don W Cleveland

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2013-10-16T00:00:00Z

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257889736

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24133140

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3816416

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